CNS infection and immune privilege

John V. Forrester, Paul G. McMenamin, Samantha J. Dando

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Classically, the CNS is described as displaying immune privilege, as it shows attenuated responses to challenge by alloantigen. However, the CNS does show local inflammation in response to infection. Although pathogen access to the brain parenchyma and retina is generally restricted by physiological and immunological barriers, certain pathogens may breach these barriers. In the CNS, such pathogens may either cause devastating inflammation or benefit from immune privilege in the CNS, where they are largely protected from the peripheral immune system. Thus, some pathogens can persist as latent infections and later be reactivated. We review the consequences of immune privilege in the context of CNS infections and ask whether immune privilege may provide protection for certain pathogens and promote their latency.

Original languageEnglish
Pages (from-to)655-671
Number of pages17
JournalNature Reviews Neuroscience
Volume19
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

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Infection
Inflammation
Isoantigens
Retina
Immune System
Brain

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Forrester, John V. ; McMenamin, Paul G. ; Dando, Samantha J. / CNS infection and immune privilege. In: Nature Reviews Neuroscience. 2018 ; Vol. 19, No. 11. pp. 655-671.
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CNS infection and immune privilege. / Forrester, John V.; McMenamin, Paul G.; Dando, Samantha J.

In: Nature Reviews Neuroscience, Vol. 19, No. 11, 01.11.2018, p. 655-671.

Research output: Contribution to journalReview article

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