TY - JOUR
T1 - Clostridium difficile infection
T2 - Evolution, phylogeny and molecular epidemiology
AU - Elliott, Briony
AU - Androga, Grace O.
AU - Knight, Daniel R.
AU - Riley, Thomas V.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Over the recent decades, Clostridium difficile infection (CDI) has emerged as a global public health threat. Despite growing attention, C. difficile remains a poorly understood pathogen, however, the exquisite sensitivity offered by next generation sequencing (NGS) technology has enabled analysis of the genome of C. difficile, giving us access to massive genomic data on factors such as virulence, evolution, and genetic relatedness within C. difficile groups. NGS has also demonstrated excellence in investigations of outbreaks and disease transmission, in both small and large-scale applications. This review summarizes the molecular epidemiology, evolution, and phylogeny of C. difficile, one of the most important pathogens worldwide in the current antibiotic resistance era.
AB - Over the recent decades, Clostridium difficile infection (CDI) has emerged as a global public health threat. Despite growing attention, C. difficile remains a poorly understood pathogen, however, the exquisite sensitivity offered by next generation sequencing (NGS) technology has enabled analysis of the genome of C. difficile, giving us access to massive genomic data on factors such as virulence, evolution, and genetic relatedness within C. difficile groups. NGS has also demonstrated excellence in investigations of outbreaks and disease transmission, in both small and large-scale applications. This review summarizes the molecular epidemiology, evolution, and phylogeny of C. difficile, one of the most important pathogens worldwide in the current antibiotic resistance era.
KW - Clostridium difficile
KW - Evolution
KW - Nosocomial infections
KW - Pathogenesis
KW - Phylogeny
UR - http://www.scopus.com/inward/record.url?scp=85007607637&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2016.12.018
DO - 10.1016/j.meegid.2016.12.018
M3 - Review article
C2 - 28012982
SN - 1567-1348
VL - 49
SP - 1
EP - 11
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
ER -