Clonal diversity in the myeloproliferative neoplasms: Independent origins of genetically distinct clones

Philip A. Beer; Amy V. Jones; Anthony J. Bench; Andrea Goday-Fernandez; Elaine M. Boyd; Krishna J. Vaghela; Wendy N. Erber; Bassam Odeh; Christine Wright; Mary Frances McMullin; Jonathan Cullis; Brian J.P. Huntly; Claire N. Harrison; Nicholas C.P. Cross; Anthony R. Green

doi:10.1111/j.1365-2141.2008.07560.x

Clonal diversity in the myeloproliferative neoplasms: Independent origins of genetically distinct clones

Philip A. Beer, Amy V. Jones, Anthony J. Bench, Andrea Goday-Fernandez, Elaine M. Boyd, Krishna J. Vaghela, Wendy N. Erber, Bassam Odeh, Christine Wright, Mary Frances McMullin, Jonathan Cullis, Brian J.P. Huntly, Claire N. Harrison, Nicholas C.P. Cross, Anthony R. Green

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently.

Original language	English
Pages (from-to)	904-908
Number of pages	5
Journal	British Journal of Haematology
Volume	144
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2141.2008.07560.x
Publication status	Published - 1 Mar 2009
Externally published	Yes

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10.1111/j.1365-2141.2008.07560.x

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Beer, P. A., Jones, A. V., Bench, A. J., Goday-Fernandez, A., Boyd, E. M., Vaghela, K. J., Erber, W. N., Odeh, B., Wright, C., McMullin, M. F., Cullis, J., Huntly, B. J. P., Harrison, C. N., Cross, N. C. P., & Green, A. R. (2009). Clonal diversity in the myeloproliferative neoplasms: Independent origins of genetically distinct clones. British Journal of Haematology, 144(6), 904-908. https://doi.org/10.1111/j.1365-2141.2008.07560.x

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title = "Clonal diversity in the myeloproliferative neoplasms: Independent origins of genetically distinct clones",

abstract = "This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently.",

keywords = "Clonality, Cytogenetics, Leukaemia, Myeloproliferative disorder, Tyrosine kinases",

author = "Beer, {Philip A.} and Jones, {Amy V.} and Bench, {Anthony J.} and Andrea Goday-Fernandez and Boyd, {Elaine M.} and Vaghela, {Krishna J.} and Erber, {Wendy N.} and Bassam Odeh and Christine Wright and McMullin, {Mary Frances} and Jonathan Cullis and Huntly, {Brian J.P.} and Harrison, {Claire N.} and Cross, {Nicholas C.P.} and Green, {Anthony R.}",

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doi = "10.1111/j.1365-2141.2008.07560.x",

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Beer, PA, Jones, AV, Bench, AJ, Goday-Fernandez, A, Boyd, EM, Vaghela, KJ, Erber, WN, Odeh, B, Wright, C, McMullin, MF, Cullis, J, Huntly, BJP, Harrison, CN, Cross, NCP & Green, AR 2009, 'Clonal diversity in the myeloproliferative neoplasms: Independent origins of genetically distinct clones', British Journal of Haematology, vol. 144, no. 6, pp. 904-908. https://doi.org/10.1111/j.1365-2141.2008.07560.x

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T2 - Independent origins of genetically distinct clones

AU - Beer, Philip A.

AU - Jones, Amy V.

AU - Bench, Anthony J.

AU - Goday-Fernandez, Andrea

AU - Boyd, Elaine M.

AU - Vaghela, Krishna J.

AU - Erber, Wendy N.

AU - Odeh, Bassam

AU - Wright, Christine

AU - McMullin, Mary Frances

AU - Cullis, Jonathan

AU - Huntly, Brian J.P.

AU - Harrison, Claire N.

AU - Cross, Nicholas C.P.

AU - Green, Anthony R.

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Y1 - 2009/3/1

N2 - This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently.

AB - This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently.

KW - Clonality

KW - Cytogenetics

KW - Leukaemia

KW - Myeloproliferative disorder

KW - Tyrosine kinases

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AN - SCOPUS:60649096136

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JO - British Journal of Haematology

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ER -

Clonal diversity in the myeloproliferative neoplasms: Independent origins of genetically distinct clones

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