Clinical value of cancer stem cell markers in colorectal cancer

Timothy James Miller

doi:10.4225/23/5a98e48209780

Clinical value of cancer stem cell markers in colorectal cancer

Timothy James Miller

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

Cancer stem-like cells (CSC) are a sub-population of tumour cells that are self-renewing, chemoresistant and highly tumourigenic. A number of markers that identify CSC have shown promise as clinically useful tools in colorectal cancer (CRC). This thesis investigated the relevance of CSC marker expression during disease progression, chemotherapy response and survival in patients with CRC. It was found that increased expression of the pluripotency-associated transcription factor SOX2 in patients' tumours was associated with reduced response to chemotherapy and poor survival outcomes. SOX2 may therefore provide a potential target for anti-CSC therapies, which could improve response and survival rates in CRC.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Platell, Cameron, Supervisor McCoy, Melanie, Supervisor Iacopetta, Barry John, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	15 Feb 2018
DOIs	https://doi.org/10.4225/23/5a98e48209780
Publication status	Unpublished - 2018

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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THESIS - DOCTOR OF PHILOSOPHY - MILLER Timothy James - 2018
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Cite this

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title = "Clinical value of cancer stem cell markers in colorectal cancer",

abstract = "Cancer stem-like cells (CSC) are a sub-population of tumour cells that are self-renewing, chemoresistant and highly tumourigenic. A number of markers that identify CSC have shown promise as clinically useful tools in colorectal cancer (CRC). This thesis investigated the relevance of CSC marker expression during disease progression, chemotherapy response and survival in patients with CRC. It was found that increased expression of the pluripotency-associated transcription factor SOX2 in patients' tumours was associated with reduced response to chemotherapy and poor survival outcomes. SOX2 may therefore provide a potential target for anti-CSC therapies, which could improve response and survival rates in CRC. ",

keywords = "Colorectal cancer, Cancer stem cells, immune cells, SOX2, FoxP3, PD-L1, CD133",

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AU - Miller, Timothy James

PY - 2018

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N2 - Cancer stem-like cells (CSC) are a sub-population of tumour cells that are self-renewing, chemoresistant and highly tumourigenic. A number of markers that identify CSC have shown promise as clinically useful tools in colorectal cancer (CRC). This thesis investigated the relevance of CSC marker expression during disease progression, chemotherapy response and survival in patients with CRC. It was found that increased expression of the pluripotency-associated transcription factor SOX2 in patients' tumours was associated with reduced response to chemotherapy and poor survival outcomes. SOX2 may therefore provide a potential target for anti-CSC therapies, which could improve response and survival rates in CRC.

AB - Cancer stem-like cells (CSC) are a sub-population of tumour cells that are self-renewing, chemoresistant and highly tumourigenic. A number of markers that identify CSC have shown promise as clinically useful tools in colorectal cancer (CRC). This thesis investigated the relevance of CSC marker expression during disease progression, chemotherapy response and survival in patients with CRC. It was found that increased expression of the pluripotency-associated transcription factor SOX2 in patients' tumours was associated with reduced response to chemotherapy and poor survival outcomes. SOX2 may therefore provide a potential target for anti-CSC therapies, which could improve response and survival rates in CRC.

KW - Colorectal cancer

KW - Cancer stem cells

KW - immune cells

KW - SOX2

KW - FoxP3

KW - PD-L1

KW - CD133

U2 - 10.4225/23/5a98e48209780

DO - 10.4225/23/5a98e48209780

M3 - Doctoral Thesis

ER -

Clinical value of cancer stem cell markers in colorectal cancer

Abstract

UN SDGs

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