Abstract
Cancer stem-like cells (CSC) are a sub-population of tumour cells that are self-renewing, chemoresistant and highly tumourigenic. A number of markers that identify CSC have shown promise as clinically useful tools in colorectal cancer (CRC). This thesis investigated the relevance of CSC marker expression during disease progression, chemotherapy response and survival in patients with CRC. It was found that increased expression of the pluripotency-associated transcription factor SOX2 in patients' tumours was associated with reduced response to chemotherapy and poor survival outcomes. SOX2 may therefore provide a potential target for anti-CSC therapies, which could improve response and survival rates in CRC.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 15 Feb 2018 |
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| Publication status | Unpublished - 2018 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - MILLER Timothy James - 2018
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