Clinical, immunological and host gene expression profiling of acute HIV infection in Africa

Erica Parker

doi:10.26182/ndea-eh59

Clinical, immunological and host gene expression profiling of acute HIV infection in Africa

Erica Parker

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

Human immunodeficiency virus (HIV) is a critical public health threat, particularly in Eastern and Southern Africa. Host immunological events during the earliest weeks of infection are important in determining onward transmission risk, and longer-term disease progression. This thesis presents a body of work exploring the role of acute HIV infection in perpetuating the HIV pandemic, the clinical and immunological features of an acute HIV cohort in Mozambique, and the host gene expression dysregulation occurring during early infection. These findings have applications in HIV diagnostic tools and monitoring assays, and offer mechanistic understandings crucial for progress toward a vaccine and cure.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Le Souef, Peter, Supervisor French, Martyn, Supervisor Naniche, Denise, Supervisor, External person
Thesis sponsors	Australian Government Research Training Program
Award date	21 Nov 2023
DOIs	https://doi.org/10.26182/ndea-eh59
Publication status	Unpublished - 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.26182/ndea-eh59

THESIS - DOCTOR OF PHILOSOPHY - PARKER Erica Louise - 2023
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Gene dysregulation in acute HIV-1 infection – early transcriptomic analysis reveals the crucial biological functions affected
Parker, E., Judge, M. A., Pastor, L., Fuente-Soro, L., Jairoce, C., Carter, K. W., Anderson, D., Mandomando, I., Clifford, H. D., Naniche, D. & Le Souëf, P. N., 3 Apr 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 17 p., 1074847.
Research output: Contribution to journal › Article › peer-review

Open Access
9 Link opens in a new tab Citations (Web of Science)
HIV infection in Eastern and Southern Africa: Highest burden, largest challenges, greatest potential
Parker, E., Judge, M. A., Macete, E., Nhampossa, T., Dorward, J., Langa, D. C., de Schacht, C., Couto, A., Vaz, P., Vitoria, M., Molfino, L., Idowu, R. T., Bhatt, N., Naniche, D. & Le Souëf, P. N., 2021, In: Southern African Journal of HIV Medicine. 22, 1, a1237.
Research output: Contribution to journal › Article › peer-review

Open Access
36 Link opens in a new tab Citations (Scopus)
Gene Expression: the Key to Understanding HIV-1 Infection?
Judge, M., Parker, E., Naniche, D. & Le Souëf, P., Jun 2020, In: Microbiology and molecular biology reviews : MMBR. 84, 2, e00080-19.
Research output: Contribution to journal › Review article › peer-review

Open Access
10 Link opens in a new tab Citations (Scopus)

Cite this

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title = "Clinical, immunological and host gene expression profiling of acute HIV infection in Africa",

abstract = "Human immunodeficiency virus (HIV) is a critical public health threat, particularly in Eastern and Southern Africa. Host immunological events during the earliest weeks of infection are important in determining onward transmission risk, and longer-term disease progression. This thesis presents a body of work exploring the role of acute HIV infection in perpetuating the HIV pandemic, the clinical and immunological features of an acute HIV cohort in Mozambique, and the host gene expression dysregulation occurring during early infection. These findings have applications in HIV diagnostic tools and monitoring assays, and offer mechanistic understandings crucial for progress toward a vaccine and cure.",

keywords = "HIV, sub-Saharan Africa, gene expression, acute infection, virology, epidemiology, infectious disease, transcriptomic analysis",

author = "Erica Parker",

year = "2023",

doi = "10.26182/ndea-eh59",

language = "English",

school = "The University of Western Australia",

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TY - BOOK

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AU - Parker, Erica

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N2 - Human immunodeficiency virus (HIV) is a critical public health threat, particularly in Eastern and Southern Africa. Host immunological events during the earliest weeks of infection are important in determining onward transmission risk, and longer-term disease progression. This thesis presents a body of work exploring the role of acute HIV infection in perpetuating the HIV pandemic, the clinical and immunological features of an acute HIV cohort in Mozambique, and the host gene expression dysregulation occurring during early infection. These findings have applications in HIV diagnostic tools and monitoring assays, and offer mechanistic understandings crucial for progress toward a vaccine and cure.

AB - Human immunodeficiency virus (HIV) is a critical public health threat, particularly in Eastern and Southern Africa. Host immunological events during the earliest weeks of infection are important in determining onward transmission risk, and longer-term disease progression. This thesis presents a body of work exploring the role of acute HIV infection in perpetuating the HIV pandemic, the clinical and immunological features of an acute HIV cohort in Mozambique, and the host gene expression dysregulation occurring during early infection. These findings have applications in HIV diagnostic tools and monitoring assays, and offer mechanistic understandings crucial for progress toward a vaccine and cure.

KW - HIV

KW - sub-Saharan Africa

KW - gene expression

KW - acute infection

KW - virology

KW - epidemiology

KW - infectious disease

KW - transcriptomic analysis

U2 - 10.26182/ndea-eh59

DO - 10.26182/ndea-eh59

M3 - Doctoral Thesis

ER -

Clinical, immunological and host gene expression profiling of acute HIV infection in Africa

Abstract

UN SDGs

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Research output

Gene dysregulation in acute HIV-1 infection – early transcriptomic analysis reveals the crucial biological functions affected

HIV infection in Eastern and Southern Africa: Highest burden, largest challenges, greatest potential

Gene Expression: the Key to Understanding HIV-1 Infection?

Cite this