Clinical, immunological and host gene expression profiling of acute HIV infection in Africa

Erica Parker

Research output: ThesisDoctoral Thesis

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Abstract

Human immunodeficiency virus (HIV) is a critical public health threat, particularly in Eastern and Southern Africa. Host immunological events during the earliest weeks of infection are important in determining onward transmission risk, and longer-term disease progression. This thesis presents a body of work exploring the role of acute HIV infection in perpetuating the HIV pandemic, the clinical and immunological features of an acute HIV cohort in Mozambique, and the host gene expression dysregulation occurring during early infection. These findings have applications in HIV diagnostic tools and monitoring assays, and offer mechanistic understandings crucial for progress toward a vaccine and cure.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Le Souef, Peter, Supervisor
  • French, Martyn, Supervisor
  • Naniche, Denise, Supervisor, External person
Thesis sponsors
Award date21 Nov 2023
DOIs
Publication statusUnpublished - 2023

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