Background: Odontogenic infections are a common presentation to emergency departments of Australian hospitals. Due to the limited training in diagnosis and treatment of dental conditions, these patients can present a challenge for the medical practitioner. The objective of this study was to provide an evidence-based approach to the management of odontogenic infections in adults presenting to Royal Perth Hospital. Methods: A literature search was conducted to identify evidence-based guidelines for the management of odontogenic infections in the tertiary hospital setting. Keywords ‘dental’, ‘infections’ and ‘management’ were used to search PubMed, DynaMed and Embase databases. Results: Recommendations were drawn from existing literature including coroner reports with respect to clinical assessment, investigations, medical and surgical management, and postoperative care. A flow chart, incorporating these recommendations, was created to allow for appropriate disposition of patients presenting with odontogenic infections to Royal Perth Hospital. Conclusions: A clinical guideline is needed to appropriately manage patients presenting with odontogenic infections. We recommend the guideline be submitted to intradepartmental committees for assessment.