TY - JOUR
T1 - Clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus among children in Qatar
AU - Haris, Basma
AU - Ahmed, Ikhlak
AU - Syed, Najeeb
AU - Almabrazi, Hakeem
AU - Saraswathi, Saras
AU - Al-Khawaga, Sara
AU - Saeed, Amira
AU - Mundekkadan, Shihab
AU - Mohammed, Idris
AU - Sharari, Sanaa
AU - Hawari, Iman
AU - Hamed, Noor
AU - Afyouni, Houda
AU - Abdel-Karim, Tasneem
AU - Mohammed, Shayma
AU - Khalifa, Amel
AU - Al-Maadheed, Maryam
AU - Zyoud, Mahmoud
AU - Shamekh, Ahmed
AU - Elawwa, Ahmed
AU - Karim, Mohammed Y
AU - Al-Khalaf, Fawziya
AU - Tatari-Calderone, Zohreh
AU - Petrovski, Goran
AU - Hussain, Khalid
PY - 2021/12
Y1 - 2021/12
N2 - To describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Patients (0-18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured. Whole Genome Sequencing was performed. Genomic data analysis was compared with the known genes linked with T1DM and HLA alleles were studied. 1096 patients had one or more antibody positivity. The incidence of T1DM in 2020 was 38.05 per 100,000 children and prevalence was 249.73. GADA was the most common autoantibody followed by IAA. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of HLA haplotypes DQA1*03:01:01G (OR = 2.46, p value = 0.011) and DQB1*03:02:01G (OR = 2.43, p value = 0.022) was identified. The incidence of T1DM in Qatar is the fourth highest in the world, IA2 autoantibody was the most specific with some patients only having ZnT8 or IA2 autoantibodies thus underlining the necessity of profiling all 4 autoantibodies. The genes associated with T1DM in the Arab population were different from those that are common in the Caucasian population. HLA-DQ was enriched in the Qatari patients suggesting that it can be considered a major risk factor at an early age.
AB - To describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Patients (0-18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured. Whole Genome Sequencing was performed. Genomic data analysis was compared with the known genes linked with T1DM and HLA alleles were studied. 1096 patients had one or more antibody positivity. The incidence of T1DM in 2020 was 38.05 per 100,000 children and prevalence was 249.73. GADA was the most common autoantibody followed by IAA. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of HLA haplotypes DQA1*03:01:01G (OR = 2.46, p value = 0.011) and DQB1*03:02:01G (OR = 2.43, p value = 0.022) was identified. The incidence of T1DM in Qatar is the fourth highest in the world, IA2 autoantibody was the most specific with some patients only having ZnT8 or IA2 autoantibodies thus underlining the necessity of profiling all 4 autoantibodies. The genes associated with T1DM in the Arab population were different from those that are common in the Caucasian population. HLA-DQ was enriched in the Qatari patients suggesting that it can be considered a major risk factor at an early age.
UR - http://www.scopus.com/inward/record.url?scp= 85115390020&partnerID=8YFLogxK
U2 - 10.1038/s41598-021-98460-4
DO - 10.1038/s41598-021-98460-4
M3 - Article
C2 - 34556755
SN - 2045-2322
VL - 11
SP - 18887
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 18887
ER -