Clinical feasibility of optical coherence elastography for tumour margin assessment in breast-conserving surgery

Wes Allen

Research output: ThesisDoctoral Thesis

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Abstract

Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to tumour being found within the margin of the excised lump, determined days following surgery. The work presented in this thesis aims to develop a wide­field optical coherence elastography system suitable for intraoperative margin assessment to reduce additional procedures. Early feasibility studies are presented investigating the ability for three optical coherence elastography variants to visualise a range of tumour morphologies In human breast tissue. The thesis demonstrates the clinical feasibility of optical coherence elastography for tumour margin assessment and provides a strong foundation for future clinical translation.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date22 Aug 2019
DOIs
Publication statusUnpublished - 2019

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