Clinical characteristics and early treatment outcomes of follicular lymphoma in young adults

Shane A Gangatharan, Manjula Maganti, John G Kuruvilla, Vishal Kukreti, Rodger E Tiedemann, Mary K Gospodarowicz, David C Hodgson, Alex Sun, Richard W Tsang, Melania Pintilie, Michael Crump

Research output: Contribution to journalArticlepeer-review

7 Citations (Web of Science)

Abstract

Follicular lymphoma (FL) in young adults (YA, <40 years old) is uncommon, and the clinical characteristics and outcomes of this group are not well defined. We conducted a retrospective database review of 427 patients with newly diagnosed FL aged 65 years or less registered at Princess Margaret Cancer Centre between 1995 and 2010. YA (n = 61) and those 40-65 (n = 366) were compared with regards to clinical stage at diagnosis, FL International Prognostic Index (FLIPI) score, and the following clinical outcomes: time to second treatment, cause-specific survival (CSS) and overall survival (OS). At diagnosis, stage and FLIPI score were similar, as were the proportion of patients requiring therapy (YA 75% versus older adults 71%). Median follow-up was 8.1 years. Time to second therapy was similar in both age groups (5-year probability 23% YA versus 27% older adults; Gray's P-value = 0.76). Ten-year OS was significantly higher for YA (87% versus older adults 72%; P = 0.029). On multivariate analysis, age <40 years, low FLIPI score and observation as initial management were favourable prognostic factors for OS and CSS. We conclude that YA with FL have a favourable prognosis compared to older patients; whether this reflects competing mortality risks or age-related differences in lymphoma biology warrants further investigation.

Original languageEnglish
Pages (from-to)384-390
Number of pages7
JournalBritish Journal of Haematology
Volume170
Issue number3
DOIs
Publication statusPublished - Aug 2015
Externally publishedYes

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