Clinical application of event-related potential (ERP) indices of response suppression

Allison Fox, Jonson Moyle

Research output: Chapter in Book/Conference paperConference paperpeer-review


Recent experimental research using functional MRI has identified possible neural substrates for the suppression of prepotent responses (deZubicaray et al., 2000), although the relatively poor temporal resolution off MRI limits the ability of this technique to identify the particular stage of information processing affected. Event-related potentials (ERPs) have excellent temporal resolution and the integration of information obtained from these complementary technologies could significantly enhance our understanding of a variety of neuropsychological disorders. The present study examined the modulation of the N2 component of the ERP, argued to reflect response inhibition, in response to the parametric manipulation of response prepotency. Proportion of false alarm errors committed and N2amplitude elicited following presentation of Nogo stimuli increased linearly with increasing response prepotency. The application of these techniques to assist our understanding of the neuropsychological impairments following traumatic brain injury will be discussed and preliminary results using a single-case analysis in a participant who had sustained multiple mild head injuries will be presented
Original languageEnglish
Title of host publicationBrain Impairment
Publication statusPublished - 2002
Event25th Annual Brain Impairment Conference - Port Macquarie, Australia
Duration: 17 May 200219 May 2002


Conference25th Annual Brain Impairment Conference


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