TY - JOUR
T1 - Clinical and translational implications of the caveolin gene family
T2 - Lessons from mouse models and human genetic disorders
AU - Mercier, Isabelle
AU - Jasmin, Jean Francois
AU - Pavlides, Stephanos
AU - Minetti, Carlo
AU - Flomenberg, Neal
AU - Pestell, Richard G.
AU - Frank, Philippe G.
AU - Sotgia, Federica
AU - Lisanti, Michael P.
N1 - Funding Information:
MPL and his laboratory were supported by grants from the NIH/NCI (R01-CA-80250; R01-CA-098779; R01-CA-120876), the American Heart Association (AHA), the Muscular Dystrophy Association (MDA), the American Association for Cancer Research (AACR), the Susan G. Komen Breast Cancer Foundation, and the Department of Defense-Breast Cancer Research Program (Synergistic Idea Award). IM was supported by a post-doctoral fellowship from the Susan G Komen Breast Cancer Foundation. PGF was supported by a grant from the WW Smith Charitable Trust, and a Career Catalyst Award from the Susan G Komen Breast Cancer Foundation. FS was supported by grants from the Breast Cancer Alliance, the Elsa U Pardee Foundation, the WW Smith Charitable Trust, and a Research Scholar Grant from the American Cancer Society (ACS). JFJ was supported by a Career Catalyst Award from the Susan G Komen Breast Cancer Foundation. RGP was supported by grants from the NIH/NCI (R01-CA-70896, R01-CA-75503, R01-CA-86072, and R01-CA-107382), and the Dr Ralph and Marian C. Falk Medical Research Trust. The Kimmel Cancer Center was supported by the NIH/NCI Cancer Center Core grant P30-CA-56036 (to RGP). This work was funded, in part, under a grant with the Pennsylvania Department of Health (to MPL). The Department specifically disclaims responsibility for any analyses, interpretations, or conclusions.
PY - 2009/6
Y1 - 2009/6
N2 - Here we review the clinical and translational implications of the caveolin gene family for understanding the pathogenesis of human diseases, including breast and prostate cancers, pulmonary hypertension, cardiomyopathy, diabetes, and muscular dystrophy. Detailed phenotypic analysis of caveolin knockout mice has served to highlight the crucial role of a caveolin deficiency in the pathogenesis of many human disease processes. Mutations in the human caveolin genes are associated with a number of established genetic disorders (such as breast cancer, lipodystrophy, muscular dystrophy, and cardiomyopathy), making the caveolins important and novel targets for drug development. The implementation of new strategies for caveolin replacement therapyincluding caveolin mimetic peptidesis ongoing.
AB - Here we review the clinical and translational implications of the caveolin gene family for understanding the pathogenesis of human diseases, including breast and prostate cancers, pulmonary hypertension, cardiomyopathy, diabetes, and muscular dystrophy. Detailed phenotypic analysis of caveolin knockout mice has served to highlight the crucial role of a caveolin deficiency in the pathogenesis of many human disease processes. Mutations in the human caveolin genes are associated with a number of established genetic disorders (such as breast cancer, lipodystrophy, muscular dystrophy, and cardiomyopathy), making the caveolins important and novel targets for drug development. The implementation of new strategies for caveolin replacement therapyincluding caveolin mimetic peptidesis ongoing.
KW - Caveolae
KW - Caveolins
KW - Human disease pathogenesis
KW - Mouse animal models
UR - http://www.scopus.com/inward/record.url?scp=66549103618&partnerID=8YFLogxK
U2 - 10.1038/labinvest.2009.23
DO - 10.1038/labinvest.2009.23
M3 - Short survey
C2 - 19333235
AN - SCOPUS:66549103618
SN - 0023-6837
VL - 89
SP - 614
EP - 623
JO - Laboratory Investigation
JF - Laboratory Investigation
IS - 6
ER -
