Clinical and immunogenetic correlates of abacavir hypersensitivity

Elizabeth J. Phillips; Gavin A. Wong; Rupert Kaul; Kamnoosh Shahabi; David A. Nolan; Sandra R. Knowles; Annalise M. Martin; Simon A. Mallal; Neil H. Shear

doi:10.1097/01.aids.0000171414.99409.fb

Clinical and immunogenetic correlates of abacavir hypersensitivity

Elizabeth J. Phillips
, Gavin A. Wong
, Rupert Kaul
, Kamnoosh Shahabi
, David A. Nolan
, Sandra R. Knowles
, Annalise M. Martin
, Simon A. Mallal
, Neil H. Shear

Research output: Contribution to journal › Article › peer-review

146 Citations (Scopus)

Abstract

A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CDS proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.

Original language	English
Pages (from-to)	979-981
Number of pages	3
Journal	AIDS
Volume	19
Issue number	9
DOIs	https://doi.org/10.1097/01.aids.0000171414.99409.fb
Publication status	Published - 10 Jun 2005
Externally published	Yes

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Cite this

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title = "Clinical and immunogenetic correlates of abacavir hypersensitivity",

abstract = "A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71\%) versus one of 11 controls (9\%) (P = 0.005) showed significant abacavir-specific CDS proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.",

author = "Phillips, \{Elizabeth J.\} and Wong, \{Gavin A.\} and Rupert Kaul and Kamnoosh Shahabi and Nolan, \{David A.\} and Knowles, \{Sandra R.\} and Martin, \{Annalise M.\} and Mallal, \{Simon A.\} and Shear, \{Neil H.\}",

year = "2005",

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T1 - Clinical and immunogenetic correlates of abacavir hypersensitivity

AU - Phillips, Elizabeth J.

AU - Wong, Gavin A.

AU - Kaul, Rupert

AU - Shahabi, Kamnoosh

AU - Nolan, David A.

AU - Knowles, Sandra R.

AU - Martin, Annalise M.

AU - Mallal, Simon A.

AU - Shear, Neil H.

PY - 2005/6/10

Y1 - 2005/6/10

N2 - A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CDS proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.

AB - A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CDS proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.

UR - https://www.scopus.com/pages/publications/20644470742

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DO - 10.1097/01.aids.0000171414.99409.fb

M3 - Article

C2 - 15905681

AN - SCOPUS:20644470742

SN - 0269-9370

VL - 19

SP - 979

EP - 981

JO - AIDS

JF - AIDS

IS - 9

ER -

Clinical and immunogenetic correlates of abacavir hypersensitivity

Abstract

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