Clinical and immunogenetic correlates of abacavir hypersensitivity

Elizabeth J. Phillips, Gavin A. Wong, Rupert Kaul, Kamnoosh Shahabi, David A. Nolan, Sandra R. Knowles, Annalise M. Martin, Simon A. Mallal, Neil H. Shear

Research output: Contribution to journalArticlepeer-review

144 Citations (Scopus)


A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CDS proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.

Original languageEnglish
Pages (from-to)979-981
Number of pages3
Issue number9
Publication statusPublished - 10 Jun 2005
Externally publishedYes


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