Clinical and immunogenetic correlates of abacavir hypersensitivity

Elizabeth J. Phillips; Gavin A. Wong; Rupert Kaul; Kamnoosh Shahabi; David A. Nolan; Sandra R. Knowles; Annalise M. Martin; Simon A. Mallal; Neil H. Shear

doi:10.1097/01.aids.0000171414.99409.fb

Clinical and immunogenetic correlates of abacavir hypersensitivity

Elizabeth J. Phillips, Gavin A. Wong, Rupert Kaul, Kamnoosh Shahabi, David A. Nolan, Sandra R. Knowles, Annalise M. Martin, Simon A. Mallal, Neil H. Shear

Research output: Contribution to journal › Article › peer-review

144 Citations (Scopus)

Abstract

A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CDS proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.

Original language	English
Pages (from-to)	979-981
Number of pages	3
Journal	AIDS
Volume	19
Issue number	9
DOIs	https://doi.org/10.1097/01.aids.0000171414.99409.fb
Publication status	Published - 10 Jun 2005
Externally published	Yes

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title = "Clinical and immunogenetic correlates of abacavir hypersensitivity",

abstract = "A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CDS proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.",

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T1 - Clinical and immunogenetic correlates of abacavir hypersensitivity

AU - Phillips, Elizabeth J.

AU - Wong, Gavin A.

AU - Kaul, Rupert

AU - Shahabi, Kamnoosh

AU - Nolan, David A.

AU - Knowles, Sandra R.

AU - Martin, Annalise M.

AU - Mallal, Simon A.

AU - Shear, Neil H.

PY - 2005/6/10

Y1 - 2005/6/10

N2 - A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CDS proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.

AB - A patch test (PT) may be useful in defining true abacavir hypersensitivity syndrome (AHS). Seven previously PT-positive patients remote from the original AHS were shown to have robust 24 h responses, supporting PT durability. HLA-B*5701 was present in all seven PT-positive versus one of 11 controls tolerating abacavir (P < 0.001). Five of seven PT (71%) versus one of 11 controls (9%) (P = 0.005) showed significant abacavir-specific CDS proliferation, suggesting a direct role for HLA-B*5701-restricted CD8 cells in the pathophysiology of AHS.

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DO - 10.1097/01.aids.0000171414.99409.fb

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AN - SCOPUS:20644470742

SN - 0269-9370

VL - 19

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EP - 981

JO - AIDS

JF - AIDS

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ER -

Clinical and immunogenetic correlates of abacavir hypersensitivity

Abstract

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