Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department

Stephen Patrick John Macdonald

doi:10.4225/23/5a6e79f871dd0

Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department

Stephen Patrick John Macdonald

Research output: Thesis › Doctoral Thesis

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Abstract

Sepsis is a life threatening complication of infection. Prompt treatment saves lives, but early sepsis can be difficult to recognise in the emergency department. This research investigated novel ways to improve sepsis diagnosis and treatment. One feature of sepsis is changes in how small blood vessels in tissues function in response to inflammation. This aspect was studied by measuring blood markers, and by bedside tests of the oxygen levels in muscle. This led to the successful implementation of a
clinical trial to investigate the effects of intravenous fluid, a common treatment in sepsis, on these pathways.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Fatovich, Daniel, Supervisor Brown, Simon, Supervisor Arendts, Glenn, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	15 Jan 2018
DOIs	https://doi.org/10.4225/23/5a6e79f871dd0
Publication status	Unpublished - 2018

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THESIS - DOCTOR OF PHILOSOPHY - MACDONALD Stephen Patrick John - 2018
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Cite this

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title = "Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department",

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AB - Sepsis is a life threatening complication of infection. Prompt treatment saves lives, but early sepsis can be difficult to recognise in the emergency department. This research investigated novel ways to improve sepsis diagnosis and treatment. One feature of sepsis is changes in how small blood vessels in tissues function in response to inflammation. This aspect was studied by measuring blood markers, and by bedside tests of the oxygen levels in muscle. This led to the successful implementation of aclinical trial to investigate the effects of intravenous fluid, a common treatment in sepsis, on these pathways.

KW - Sepsis

KW - Shock, septic

KW - Emergency Service, Hospital

KW - biomarkers

KW - microcirculation

KW - Spectroscopy, infrared

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M3 - Doctoral Thesis

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Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department

Abstract

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