Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department

Stephen Patrick John Macdonald

    Research output: Thesis › Doctoral Thesis

    Abstract

    Sepsis is a life threatening complication of infection. Prompt treatment saves lives, but early sepsis can be difficult to recognise in the emergency department. This research investigated novel ways to improve sepsis diagnosis and treatment. One feature of sepsis is changes in how small blood vessels in tissues function in response to inflammation. This aspect was studied by measuring blood markers, and by bedside tests of the oxygen levels in muscle. This led to the successful implementation of a
    clinical trial to investigate the effects of intravenous fluid, a common treatment in sepsis, on these pathways.
    LanguageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Fatovich, Daniel, Supervisor
    • Brown, Simon, Supervisor
    • Arendts, Glenn, Supervisor
    Thesis sponsors
    Award date15 Jan 2018
    DOIs
    StateUnpublished - 2018

    Fingerprint

    Hospital Emergency Service
    Sepsis
    Biomarkers
    Blood Vessels
    Clinical Trials
    Oxygen
    Inflammation
    Muscles
    Infection
    Research

    Cite this

    Macdonald, Stephen Patrick John. / Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department. 2018.
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    keywords = "Sepsis, Shock, septic, Emergency Service, Hospital, biomarkers, microcirculation, Spectroscopy, infrared",
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    language = "English",
    school = "The University of Western Australia",

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    Macdonald, SPJ 2018, 'Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department', Doctor of Philosophy, The University of Western Australia. DOI: 10.4225/23/5a6e79f871dd0

    Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department. / Macdonald, Stephen Patrick John.

    2018.

    Research output: Thesis › Doctoral Thesis

    TY - THES

    T1 - Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department

    AU - Macdonald,Stephen Patrick John

    PY - 2018

    Y1 - 2018

    N2 - Sepsis is a life threatening complication of infection. Prompt treatment saves lives, but early sepsis can be difficult to recognise in the emergency department. This research investigated novel ways to improve sepsis diagnosis and treatment. One feature of sepsis is changes in how small blood vessels in tissues function in response to inflammation. This aspect was studied by measuring blood markers, and by bedside tests of the oxygen levels in muscle. This led to the successful implementation of aclinical trial to investigate the effects of intravenous fluid, a common treatment in sepsis, on these pathways.

    AB - Sepsis is a life threatening complication of infection. Prompt treatment saves lives, but early sepsis can be difficult to recognise in the emergency department. This research investigated novel ways to improve sepsis diagnosis and treatment. One feature of sepsis is changes in how small blood vessels in tissues function in response to inflammation. This aspect was studied by measuring blood markers, and by bedside tests of the oxygen levels in muscle. This led to the successful implementation of aclinical trial to investigate the effects of intravenous fluid, a common treatment in sepsis, on these pathways.

    KW - Sepsis

    KW - Shock, septic

    KW - Emergency Service, Hospital

    KW - biomarkers

    KW - microcirculation

    KW - Spectroscopy, infrared

    U2 - 10.4225/23/5a6e79f871dd0

    DO - 10.4225/23/5a6e79f871dd0

    M3 - Doctoral Thesis

    ER -

    Macdonald SPJ. Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department. 2018. Available from, DOI: 10.4225/23/5a6e79f871dd0

    Access to Document

    • THESIS - DOCTOR OF PHILOSOPHY - MACDONALD Stephen Patrick John - 2018

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