Clinical and biomarker evaluation of microcirculatory alterations in sepsis in the emergency department

Stephen Patrick John Macdonald

    Research output: Thesis › Doctoral Thesis

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    Abstract

    Sepsis is a life threatening complication of infection. Prompt treatment saves lives, but early sepsis can be difficult to recognise in the emergency department. This research investigated novel ways to improve sepsis diagnosis and treatment. One feature of sepsis is changes in how small blood vessels in tissues function in response to inflammation. This aspect was studied by measuring blood markers, and by bedside tests of the oxygen levels in muscle. This led to the successful implementation of a
    clinical trial to investigate the effects of intravenous fluid, a common treatment in sepsis, on these pathways.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Fatovich, Daniel, Supervisor
    • Brown, Simon, Supervisor
    • Arendts, Glenn, Supervisor
    Thesis sponsors
    Award date15 Jan 2018
    DOIs
    Publication statusUnpublished - 2018

    Access to Document

    • THESIS - DOCTOR OF PHILOSOPHY - MACDONALD Stephen Patrick John - 2018

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