Classification of biological micro-objects using optical coherence tomography: In silico study

Paweł Ossowski, Maciej Wojtkowski, Peter R.T. Munro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report on the development of a technique for differentiating between biological micro-objects using a rigorous, full-wave model of OCT image formation. We model an existing experimental prototype which uses OCT to interrogate a microfluidic chip containing the blood cells. A full-wave model is required since the technique uses light back-scattered by a scattering substrate, rather than by the cells directly. The light back-scattered by the substrate is perturbed upon propagation through the cells, which flow between the substrate and imaging system’s objective lens. We present the key elements of the 3D, Maxwell equation-based computational model, the key findings of the computational study and a comparison with experimental results.

Original languageEnglish
Article number290202
Pages (from-to)3606-3626
Number of pages21
JournalBiomedical Optics Express
Volume8
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017

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