Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children

C. Sengler, A. Heinzmann, S.P. Jerkic, A. Haider, C. Sommerfeld, B. Niggemann, S. Lau, J. Forster, A. Schuster, W. Kamin, C. Bauer, Ingrid Laing, Peter Le Souef, [No Value] Wahn U., [No Value] Deichmann K., [No Value] Nickel R.

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    64 Citations (Scopus)


    Background: Several studies have indicated linkage of chromosome 11q12-13 to asthma and associated traits. Among other candidate genes, the Clara cell protein 16 (CC16) gene maps to this region. CC16 is expressed in the bronchial epithelium and exhibits potent anti-inflammatory properties. A single-nucleotide polymorphism (SNP) in the CC16 gene (A38G) was previously associated with asthma.Objective: We evaluated the role of the CC16 SNP in pediatric asthma and asthma severity in 2 German study populations.Methods: The German Multicenter Allergy Study (MAS) cohort (n = 872, 94 asthmatic patients) and 112 allergic asthmatic children recruited in Freiburg, Germany, were included in the present study. Histamine provocations were performed at the age of 7 years in the MAS cohort to determine bronchial hyperreactivity; in the Freiburg study population a standardized exercise-induced decrease in FEV1 was evaluated. For genotyping, melting-curve analysis and restriction enzyme digestion were applied.Results: No association of the CC16*38A allele with asthma could be observed in either study population. However, in asthmatic subjects (MAS cohort) PC20FEV1 values were significantly lower in individuals homozygous or heterozygous for the CC16*38A allele compared with those in subjects with the CC16*38GG genotype (P <.05 and P <.03, respectively). Similarly, allergic asthmatic patients in the Freiburg cohort showed a significantly greater decrease in FEV1 after exercise when homozygous for the CC16*38A allele compared with that seen in asthmatic patients with the *38AG or *38GG genotype (P < .04 and P =.006, respectively).Conclusion: We conclude that the CC16*A38G SNP influences bronchial hyperreactivity and might be a genetic determinant of asthma severity in German children. (J Allergy Clin Immunol 2003;111:515-9.).
    Original languageEnglish
    Pages (from-to)515-519
    JournalJournal of Allergy and Clinical Immunology
    Issue number3
    Publication statusPublished - 2003


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