Projects per year
Abstract
Lipocalin-2 (LCN2) is released by several cell types including osteoblasts and adipocytes and has been suggested as a marker of renal dysfunction, metabolic syndrome (MetS) and type 2 diabetes (T2D). Whether LCN2 is linked to these diseases in older women remains unknown. This study investigated whether LCN2 is related to features of MetS and T2D in older women. This cross-sectional study included 705 non-diabetic women (mean age 75.1 ± 2.6 years) for MetS analysis and 76 women (mean age 75.4 ± 2.8 years) with T2D. Total circulating LCN2 levels were analysed using a two-step chemiluminescent microparticle monoclonal immunoassay. MetS was determined by a modified National Cholesterol Education Program Adult Treatment Panel III classification. Multivariable-adjusted logistic regression analysis was used to assess odds ratios between LCN2 quartiles and MetS. Women in the highest LCN2 quartile had approximately 3 times greater risk for MetS compared to women in the lowest quartile (OR 3.05; 95%CI 1.86–5.02). Women with T2D or MetS scores of ≥ 3 had higher LCN2 levels compared to women with a MetS score of 0 (p < 0.05). Higher LCN2 correlated with higher body mass index, fat mass, triglycerides and glycated haemoglobin and lower high-density lipoprotein cholesterol and estimated glomerular filtration rate (p < 0.05). Higher circulating levels of LCN2 are associated with worsened cardio-metabolic risk factors and increased odds of MetS and T2D in older women. Whether it can be used as a biomarker for identifying those at risk for MetS and T2D should be explored further.
Original language | English |
---|---|
Article number | 116861 |
Number of pages | 7 |
Journal | Bone |
Volume | 176 |
DOIs | |
Publication status | Published - Nov 2023 |
Fingerprint
Dive into the research topics of 'Circulating lipocalin-2 and features of metabolic syndrome in community-dwelling older women: A cross-sectional study'. Together they form a unique fingerprint.Projects
- 3 Finished
-
Determinants of Musculoskeletal and Other Diseases, Health Service Utilisation and Mortality in a Cohort of Older Women
Zhu, K. (Investigator 01), Prince, R. (Investigator 02), Flicker, L. (Investigator 03) & Mukhtar, S. (Investigator 04)
NHMRC National Health and Medical Research Council
31/12/08 → 31/12/13
Project: Research
-
Environmental and Metabolic Influences on Musculoskeletal and other Diseases in a Cohort of Elderly Women
Prince, R. (Chief Investigator), Devine, A. (Chief Investigator), Thompson, P. (Chief Investigator), Dhaliwal, S. S. (Chief Investigator) & Dick, I. (Chief Investigator)
1/01/04 → 31/12/08
Project: Research
-
Extension of the Calcium Intake Fracture Outcome Study
Prince, R. (Chief Investigator), Devine, A. (Chief Investigator), Dhaliwal, S. S. (Chief Investigator) & Dick, I. (Chief Investigator)
1/01/03 → 31/12/04
Project: Research