Circulating immune cells in multiple sclerosis

A. P. Jones, A. G. Kermode, R. M. Lucas, W. M. Carroll, D. Nolan, P. H. Hart

Research output: Contribution to journalReview article

21 Citations (Scopus)
155 Downloads (Pure)

Abstract

Circulating T and B lymphocytes contribute to the pathogenesis of the neuroinflammatory autoimmune disease, multiple sclerosis (MS). Further progress in the development of MS treatments is dependent upon a greater understanding of the immunological disturbances that underlie the disease. Analyses of circulating immune cells by flow cytometry have revealed MS-associated alterations in the composition and function of T and B cell subsets, including temporal changes associated with disease activity. Disturbances in circulating immune populations reflect those observed in the central nervous system and include skewing towards proinflammatory CD4+ and CD8+ T cells and B cells, greater proportions of follicular T helper cells and functional defects in the corresponding T and B regulatory subsets. Utilizing the analytical power of modern flow cytometers, researchers are now well positioned to monitor immunological changes associated with disease activity or intervention, describe immunological signatures with predictive value and identify targets for therapeutic drug development. This review discusses the contribution of various T and B lymphocyte subsets to MS pathogenesis, provides current and relevant phenotypical descriptions to assist in experimental design and highlights areas of future research.

Original languageEnglish
Pages (from-to)193-203
Number of pages11
JournalClinical and Experimental Immunology
Volume187
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

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Multiple Sclerosis
B-Lymphocyte Subsets
T-Lymphocyte Subsets
B-Lymphocytes
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Autoimmune Diseases
Flow Cytometry
Research Design
Central Nervous System
Research Personnel
Pharmaceutical Preparations
Population
Therapeutics

Cite this

Jones, A. P. ; Kermode, A. G. ; Lucas, R. M. ; Carroll, W. M. ; Nolan, D. ; Hart, P. H. / Circulating immune cells in multiple sclerosis. In: Clinical and Experimental Immunology. 2017 ; Vol. 187, No. 2. pp. 193-203.
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Circulating immune cells in multiple sclerosis. / Jones, A. P.; Kermode, A. G.; Lucas, R. M.; Carroll, W. M.; Nolan, D.; Hart, P. H.

In: Clinical and Experimental Immunology, Vol. 187, No. 2, 01.02.2017, p. 193-203.

Research output: Contribution to journalReview article

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AU - Kermode, A. G.

AU - Lucas, R. M.

AU - Carroll, W. M.

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AU - Hart, P. H.

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AB - Circulating T and B lymphocytes contribute to the pathogenesis of the neuroinflammatory autoimmune disease, multiple sclerosis (MS). Further progress in the development of MS treatments is dependent upon a greater understanding of the immunological disturbances that underlie the disease. Analyses of circulating immune cells by flow cytometry have revealed MS-associated alterations in the composition and function of T and B cell subsets, including temporal changes associated with disease activity. Disturbances in circulating immune populations reflect those observed in the central nervous system and include skewing towards proinflammatory CD4+ and CD8+ T cells and B cells, greater proportions of follicular T helper cells and functional defects in the corresponding T and B regulatory subsets. Utilizing the analytical power of modern flow cytometers, researchers are now well positioned to monitor immunological changes associated with disease activity or intervention, describe immunological signatures with predictive value and identify targets for therapeutic drug development. This review discusses the contribution of various T and B lymphocyte subsets to MS pathogenesis, provides current and relevant phenotypical descriptions to assist in experimental design and highlights areas of future research.

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