TY - JOUR
T1 - Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity
AU - Hung, Joe
AU - Mcquillan, Brendan
AU - Thompson, Peter
AU - Beilby, John
PY - 2008
Y1 - 2008
N2 - Background: Adiponectin is an abundantly expressed adipocyte-specific protein, whose level is decreased in obesity, and which appears to be a key participant in developing inflammation, insulin resistance and metabolic syndrome (MetS). We examined whether the relationship between adiponectin and inflammatory markers, insulin resistance and MetS was independent of obesity.Methods and results: The study was performed in 1094 men and women, aged 27–77 years, from a representative community population. We measured serum inflammatory markers, homoeostasis model assessment of insulin resistance (HOMA-IR) and prevalent MetS using National Cholesterol Education Program ATPIII criteria. Sex- and age-adjusted plasma adiponectin concentration was inversely correlated with body mass index (BMI), waist–hip ratio, diastolic blood pressure, triglycerides, glucose and fasting insulin, and positively correlated with HDL cholesterol (all P
AB - Background: Adiponectin is an abundantly expressed adipocyte-specific protein, whose level is decreased in obesity, and which appears to be a key participant in developing inflammation, insulin resistance and metabolic syndrome (MetS). We examined whether the relationship between adiponectin and inflammatory markers, insulin resistance and MetS was independent of obesity.Methods and results: The study was performed in 1094 men and women, aged 27–77 years, from a representative community population. We measured serum inflammatory markers, homoeostasis model assessment of insulin resistance (HOMA-IR) and prevalent MetS using National Cholesterol Education Program ATPIII criteria. Sex- and age-adjusted plasma adiponectin concentration was inversely correlated with body mass index (BMI), waist–hip ratio, diastolic blood pressure, triglycerides, glucose and fasting insulin, and positively correlated with HDL cholesterol (all P
U2 - 10.1038/sj.ijo.0803793
DO - 10.1038/sj.ijo.0803793
M3 - Article
C2 - 18253163
SN - 0307-0565
VL - 32
SP - 772
EP - 779
JO - International Journal of Obesity
JF - International Journal of Obesity
ER -
