Circadian regulation of hypothalamic kiss1 in neonatal development, adulthood and pregnancy in the mouse

Cassandra Ching Lin Yap

    Research output: Thesis › Doctoral Thesis

    325 Downloads (Pure)

    Abstract

    Kisspeptin, product of the Kiss1 gene, drives the hypothalamic-pituitary-gonadal (HPG) axis and is crucial for reproduction and pubertal maturation. This thesis investigated diurnal changes in Kiss1 expression in the hypothalamus during adulthood, pregnancy, and neonatal development. The kisspeptin circadian rhythm that is observed in proestrus females and is responsible for the pre-ovulatory GnRH/LH surge, is suppressed during pregnancy. This is due, in part, to the influence of progesterone and prolactin, hormones crucial for pregnancy maintenance. The kisspeptin circadian rhythm does not appear to begin before puberty, likely because clock gene rhythmicity is not fully established.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Smith, Jeremy, Supervisor
    • Mark, Peter, Supervisor
    • Waddell, Brendan, Supervisor
    Award date11 Oct 2016
    Publication statusUnpublished - 2016

    Access to Document

    • THESIS_DOCTOR_OF_PHILOSOPHY_YAP_Cassandra_Ching_Lin_2016.pdf

      This work is protected by Copyright. You may print or download ONE copy of this document for the purpose of your own non-commercial research or study. Any other use requires permission from the copyright owner. The Copyright Act requires you to attribute any copyright works you quote or paraphrase.

      Fingerprint

      Dive into the research topics of 'Circadian regulation of hypothalamic kiss1 in neonatal development, adulthood and pregnancy in the mouse'. Together they form a unique fingerprint.
      View full fingerprint

      Cite this