Cigarette smoking and pancreatic cancer risk: more to the story than just pack-years

Annaka Schulte; Nirmala Pandeya; Bich  Tran; Jonathan Fawcett; Lin Fritschi; Harvey A. Risch; Penelope M. Webb; David C. Whiteman; Rachel E. Neale; Queensland Pancreatic Canc Study G

doi:10.1016/j.ejca.2013.12.014

Cigarette smoking and pancreatic cancer risk: more to the story than just pack-years

Annaka Schulte, Nirmala Pandeya, Bich Tran, Jonathan Fawcett, Lin Fritschi, Harvey A. Risch, Penelope M. Webb, David C. Whiteman, Rachel E. Neale, Queensland Pancreatic Canc Study G

UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research)

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Purpose: Cigarette smoking is an established risk factor for pancreatic adenocarcinoma. However, few studies have thoroughly investigated the effects of independent smoking dimensions (duration, intensity, cumulative dose and time since quitting) on risk estimates. We analysed data from the Queensland Pancreatic Cancer Study (QPCS), an Australian population-based case-control study, with the aim of determining which smoking component is primarily important to pancreatic cancer risk.

Methods: Our study included 705 pancreatic cancer patients and 711 controls. Logistic regression and generalised additive logistic regression (for non-linear dose effects) were used to determine odds ratios (ORs) and 95% confidence intervals (CIs).

Results: Compared to never-smokers, current smokers had an increased risk of pancreatic cancer (OR = 3.4; 95% CI 2.4-5.0) after adjustment for age, sex, education, alcohol intake and birth country. Of the various smoking dimensions, smoking duration and time since quitting had a greater effect on OR estimates (OR 1.3; 95% CI 1.1-1.4 and OR 0.8; 95% CI 0.7-0.8) than smoking intensity (OR 1.1; 95% CI 0.9-1.2), once ever-smoking was accounted for.

Conclusions: This study confirms the association between cigarette smoking and pancreatic adenocarcinoma, and provides evidence to suggest that smoking pattern, in addition to dose effect, may affect disease risk. (C) 2014 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	997-1003
Number of pages	7
Journal	European Journal of Cancer
Volume	50
Issue number	5
Early online date	21 Jan 2014
DOIs	https://doi.org/10.1016/j.ejca.2013.12.014
Publication status	Published - Mar 2014

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10.1016/j.ejca.2013.12.014

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title = "Cigarette smoking and pancreatic cancer risk: more to the story than just pack-years",

abstract = "Purpose: Cigarette smoking is an established risk factor for pancreatic adenocarcinoma. However, few studies have thoroughly investigated the effects of independent smoking dimensions (duration, intensity, cumulative dose and time since quitting) on risk estimates. We analysed data from the Queensland Pancreatic Cancer Study (QPCS), an Australian population-based case-control study, with the aim of determining which smoking component is primarily important to pancreatic cancer risk.Methods: Our study included 705 pancreatic cancer patients and 711 controls. Logistic regression and generalised additive logistic regression (for non-linear dose effects) were used to determine odds ratios (ORs) and 95% confidence intervals (CIs).Results: Compared to never-smokers, current smokers had an increased risk of pancreatic cancer (OR = 3.4; 95% CI 2.4-5.0) after adjustment for age, sex, education, alcohol intake and birth country. Of the various smoking dimensions, smoking duration and time since quitting had a greater effect on OR estimates (OR 1.3; 95% CI 1.1-1.4 and OR 0.8; 95% CI 0.7-0.8) than smoking intensity (OR 1.1; 95% CI 0.9-1.2), once ever-smoking was accounted for.Conclusions: This study confirms the association between cigarette smoking and pancreatic adenocarcinoma, and provides evidence to suggest that smoking pattern, in addition to dose effect, may affect disease risk. (C) 2014 Elsevier Ltd. All rights reserved.",

keywords = "Pancreatic neoplasms, Smoking, Risk factors, TOTAL EXPOSURE, LUNG-CANCER, INTENSITY, METAANALYSIS, CONSORTIUM, OBESITY, TOBACCO, COHORT",

author = "Annaka Schulte and Nirmala Pandeya and Bich Tran and Jonathan Fawcett and Lin Fritschi and Risch, {Harvey A.} and Webb, {Penelope M.} and Whiteman, {David C.} and Neale, {Rachel E.} and {Queensland Pancreatic Canc Study G}",

year = "2014",

month = mar,

doi = "10.1016/j.ejca.2013.12.014",

language = "English",

volume = "50",

pages = "997--1003",

journal = "European Journal of Cancer",

issn = "0959-8049",

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number = "5",

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T1 - Cigarette smoking and pancreatic cancer risk: more to the story than just pack-years

AU - Schulte, Annaka

AU - Pandeya, Nirmala

AU - Tran, Bich

AU - Fawcett, Jonathan

AU - Fritschi, Lin

AU - Risch, Harvey A.

AU - Webb, Penelope M.

AU - Whiteman, David C.

AU - Neale, Rachel E.

AU - Queensland Pancreatic Canc Study G

PY - 2014/3

Y1 - 2014/3

N2 - Purpose: Cigarette smoking is an established risk factor for pancreatic adenocarcinoma. However, few studies have thoroughly investigated the effects of independent smoking dimensions (duration, intensity, cumulative dose and time since quitting) on risk estimates. We analysed data from the Queensland Pancreatic Cancer Study (QPCS), an Australian population-based case-control study, with the aim of determining which smoking component is primarily important to pancreatic cancer risk.Methods: Our study included 705 pancreatic cancer patients and 711 controls. Logistic regression and generalised additive logistic regression (for non-linear dose effects) were used to determine odds ratios (ORs) and 95% confidence intervals (CIs).Results: Compared to never-smokers, current smokers had an increased risk of pancreatic cancer (OR = 3.4; 95% CI 2.4-5.0) after adjustment for age, sex, education, alcohol intake and birth country. Of the various smoking dimensions, smoking duration and time since quitting had a greater effect on OR estimates (OR 1.3; 95% CI 1.1-1.4 and OR 0.8; 95% CI 0.7-0.8) than smoking intensity (OR 1.1; 95% CI 0.9-1.2), once ever-smoking was accounted for.Conclusions: This study confirms the association between cigarette smoking and pancreatic adenocarcinoma, and provides evidence to suggest that smoking pattern, in addition to dose effect, may affect disease risk. (C) 2014 Elsevier Ltd. All rights reserved.

AB - Purpose: Cigarette smoking is an established risk factor for pancreatic adenocarcinoma. However, few studies have thoroughly investigated the effects of independent smoking dimensions (duration, intensity, cumulative dose and time since quitting) on risk estimates. We analysed data from the Queensland Pancreatic Cancer Study (QPCS), an Australian population-based case-control study, with the aim of determining which smoking component is primarily important to pancreatic cancer risk.Methods: Our study included 705 pancreatic cancer patients and 711 controls. Logistic regression and generalised additive logistic regression (for non-linear dose effects) were used to determine odds ratios (ORs) and 95% confidence intervals (CIs).Results: Compared to never-smokers, current smokers had an increased risk of pancreatic cancer (OR = 3.4; 95% CI 2.4-5.0) after adjustment for age, sex, education, alcohol intake and birth country. Of the various smoking dimensions, smoking duration and time since quitting had a greater effect on OR estimates (OR 1.3; 95% CI 1.1-1.4 and OR 0.8; 95% CI 0.7-0.8) than smoking intensity (OR 1.1; 95% CI 0.9-1.2), once ever-smoking was accounted for.Conclusions: This study confirms the association between cigarette smoking and pancreatic adenocarcinoma, and provides evidence to suggest that smoking pattern, in addition to dose effect, may affect disease risk. (C) 2014 Elsevier Ltd. All rights reserved.

KW - Pancreatic neoplasms

KW - Smoking

KW - Risk factors

KW - TOTAL EXPOSURE

KW - LUNG-CANCER

KW - INTENSITY

KW - METAANALYSIS

KW - CONSORTIUM

KW - OBESITY

KW - TOBACCO

KW - COHORT

U2 - 10.1016/j.ejca.2013.12.014

DO - 10.1016/j.ejca.2013.12.014

M3 - Article

C2 - 24461200

SN - 0959-8049

VL - 50

SP - 997

EP - 1003

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 5

ER -

Cigarette smoking and pancreatic cancer risk: more to the story than just pack-years

Abstract

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