Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: A FIELD substudy

J.A. Harmer, A.C. Keech, A.S. Veillard, M.R. Skilton, T.H. Marwick, Gerald Watts, I.T. Meredith, D. Celermajer

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    © 2014 Elsevier Ireland Ltd. Aim: Impaired arterial function has been implicated in diabetes-related atherosclerosis, but its determinants in high-risk adults have not been well characterised. We investigated factors associated with impaired arterial function in adults with type 2 diabetes. Methods: Flow-mediated dilatation (a marker of endothelial function) and dilator response to glyceryl trinitrate (to assess smooth muscle function) of the brachial artery were assessed at baseline in 193 patients with type 2 diabetes from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Traditional risk factors were assessed and a multivariable model was constructed to identify factors independently associated with impaired arterial function. Results: Median age was 64 years (interquartile range, 58-69; 61% male) and duration of diabetes was 4 years (interquartile range, 2-9). Flow-mediated dilatation (3.06. ±. 0.25%, mean. ±. SEM) was severely impaired but not significantly associated with other risk factors. Dilator responses to glyceryl trinitrate (10.56. ±. 0.52%) were significantly and independently impaired in past and present cigarette smokers (P=0.005) and in subjects with increased urinary albumin/creatinine ratio (P=0.01). Conclusions: In adults with type 2 diabetes and known or suspected atherosclerosis, arterial smooth muscle-dependent dilatation was shown to be significantly impaired in cigarette smokers and those with elevated urinary albumin levels.
    Original languageEnglish
    Pages (from-to)328-336
    Number of pages9
    JournalDiabetes Research and Clinical Practice
    Volume106
    Issue number2
    Early online date16 Sept 2014
    DOIs
    Publication statusPublished - Nov 2014

    Fingerprint

    Dive into the research topics of 'Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: A FIELD substudy'. Together they form a unique fingerprint.

    Cite this