Chronic Wound Research: an integrated approach

Hilary Wallace, Michael Stacey

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    For 20 years a significant research component has been integrated into the clinical services provided for patients with chronicleg wounds at Fremantle Hospital. The development of a team of clinicians, nurses and scientists has enabled a broad range ofclinical and laboratory wound research to be undertaken on human subjects, which is only possible in a small number of centresworldwide. The key areas of research focus have been chronic wound epidemiology, clinical investigations, exercise and venousdisease, pathophysiology of venous leg ulceration and clinical trials. Research on the pathophysiology of venous leg ulcerationhas been facilitated by the development of a human model of non-healing and healing venous ulcers. More recently, a geneticapproach has been used to identify key molecules in venous ulcer pathogenesis through the investigation of gene polymorphismsas risk factors for the development of venous leg ulceration.Genetic studies and randomised control trials for chronic wound therapies require large numbers of subjects to provide adequatestatistical power. Additional funding and leadership is required to increase the number of centres across Australia with thecapacity to participate in multi-centre chronic wound studies, and to facilitate effective collaborations between hospital- and community-based wound care providers, research institutions and industry
    Original languageEnglish
    Pages (from-to)110-114
    JournalWound Practice and Research
    Issue number3
    Publication statusPublished - 2008


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