Chronic disease comorbidity in patients with oral leukoplakia

Research output: Contribution to journalReview article

Abstract

Oral leukoplakia represents the most common oral potentially malignant disorder. While a number of risk factors have been identified, its aetiology remains incompletely understood, and prediction of disease progression, stability or regression, a significant challenge. While excision is often the recommended treatment to reduce the risk of malignancy, this is not always possible and ultimately numerous disease and patient characteristics impact on the decision to initiate treatment or recommend surveillance. At present, the coexistence and impact of chronic diseases in oral leukoplakia patients remains largely unexplored, yet has the potential to significantly impact on diagnosis, treatment decisions, treatment outcomes and prognosis. Exploration of comorbid conditions in oral leukoplakia may additionally lead to greater insight of risk factors and disease pathogenesis and potentially offer more opportunities for screening and early disease detection. The aim of this review is to stimulate discussion about the role of chronic diseases comorbidity in oral leukoplakia.
LanguageEnglish
Number of pages10
JournalOral Cancer
DOIs
Publication statusE-pub ahead of print - 2 Jan 2019

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Oral Leukoplakia
Comorbidity
Chronic Disease
Disease Progression
Early Diagnosis
Therapeutics
Neoplasms

Cite this

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title = "Chronic disease comorbidity in patients with oral leukoplakia",
abstract = "Oral leukoplakia represents the most common oral potentially malignant disorder. While a number of risk factors have been identified, its aetiology remains incompletely understood, and prediction of disease progression, stability or regression, a significant challenge. While excision is often the recommended treatment to reduce the risk of malignancy, this is not always possible and ultimately numerous disease and patient characteristics impact on the decision to initiate treatment or recommend surveillance. At present, the coexistence and impact of chronic diseases in oral leukoplakia patients remains largely unexplored, yet has the potential to significantly impact on diagnosis, treatment decisions, treatment outcomes and prognosis. Exploration of comorbid conditions in oral leukoplakia may additionally lead to greater insight of risk factors and disease pathogenesis and potentially offer more opportunities for screening and early disease detection. The aim of this review is to stimulate discussion about the role of chronic diseases comorbidity in oral leukoplakia.",
author = "Agnieszka Frydrych and Omar Kujan and Camile Farah",
year = "2019",
month = "1",
day = "2",
doi = "10.1007/s41548-018-0015-y",
language = "English",
journal = "Oral Cancer",
issn = "2509-8837",
publisher = "Springer",

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Chronic disease comorbidity in patients with oral leukoplakia. / Frydrych, Agnieszka; Kujan, Omar; Farah, Camile.

In: Oral Cancer, 02.01.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Chronic disease comorbidity in patients with oral leukoplakia

AU - Frydrych, Agnieszka

AU - Kujan, Omar

AU - Farah, Camile

PY - 2019/1/2

Y1 - 2019/1/2

N2 - Oral leukoplakia represents the most common oral potentially malignant disorder. While a number of risk factors have been identified, its aetiology remains incompletely understood, and prediction of disease progression, stability or regression, a significant challenge. While excision is often the recommended treatment to reduce the risk of malignancy, this is not always possible and ultimately numerous disease and patient characteristics impact on the decision to initiate treatment or recommend surveillance. At present, the coexistence and impact of chronic diseases in oral leukoplakia patients remains largely unexplored, yet has the potential to significantly impact on diagnosis, treatment decisions, treatment outcomes and prognosis. Exploration of comorbid conditions in oral leukoplakia may additionally lead to greater insight of risk factors and disease pathogenesis and potentially offer more opportunities for screening and early disease detection. The aim of this review is to stimulate discussion about the role of chronic diseases comorbidity in oral leukoplakia.

AB - Oral leukoplakia represents the most common oral potentially malignant disorder. While a number of risk factors have been identified, its aetiology remains incompletely understood, and prediction of disease progression, stability or regression, a significant challenge. While excision is often the recommended treatment to reduce the risk of malignancy, this is not always possible and ultimately numerous disease and patient characteristics impact on the decision to initiate treatment or recommend surveillance. At present, the coexistence and impact of chronic diseases in oral leukoplakia patients remains largely unexplored, yet has the potential to significantly impact on diagnosis, treatment decisions, treatment outcomes and prognosis. Exploration of comorbid conditions in oral leukoplakia may additionally lead to greater insight of risk factors and disease pathogenesis and potentially offer more opportunities for screening and early disease detection. The aim of this review is to stimulate discussion about the role of chronic diseases comorbidity in oral leukoplakia.

U2 - 10.1007/s41548-018-0015-y

DO - 10.1007/s41548-018-0015-y

M3 - Review article

JO - Oral Cancer

T2 - Oral Cancer

JF - Oral Cancer

SN - 2509-8837

ER -