Chromosomal clustering of nuclear genes encoding mitochondrial and chloroplast proteins in Arabidopsis

A. Alexeyenko, Harvey Millar, James Whelan, E.L.L. Sonnhammer

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We present a statistical analysis of chromosomal clustering among nuclear genes encoding mitochondrial or chloroplast proteins in Arabidopsis. For both organelles, the clustering was significantly increased above the expectation, but the clustering effect was weak, and most clusters were small and dispersed. Clustered genes showed coexpression but not more than expected, and no substantial synteny was detected in other eukaryotic genomes. We propose that the unexpected clustering results from continuous selection favoring chromosomal proximity of genes acting in the same organelle.
Original languageEnglish
Pages (from-to)589-593
JournalTrends in Genetics
Volume22
Issue number11
DOIs
Publication statusPublished - 2006

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