Chitosan-Alginate-CaCl2 System for Membrane Coat Application

L. Wang, E. Khor, Lee Yong Lim

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    99 Citations (Scopus)


    Water-based formulations are preferred for membrane coat application because they do not require the use of noxious solvents. A novel aqueous chitosanalginate-CaCl2 system was evaluated as a potential formulation to produce water-insoluble membranes of biodegradable polymers. Chitosan-alginate coacervates were prepared by controlled reaction of chitosan (0.25% w/v) and sodium alginate (0.25% w/v) solutions. Coherent membranes were obtained by casting and drying the coacervates suspended in aqueous CaCl2 solutions (0.05-0.07% w/v). Increasing the calcium content did not modify membrane thickness (25-26 mum), but reduced the water vapor transmission rate from 658 to 566 g/m(2)/day, and improved the tensile strength of the membranes from 9.33 to 17.13 MPa. Differential scanning calorimetry, Fourier transform infrared spectroscopy, and elemental analyses of the chitosan-alginate coacervates indicated they were stable for up to 4 weeks of storage in distilled water at ambient temperature. Membranes of the stored coacervates required less calcium to attain maximum mechanical strength. They also had higher water vapor transmission rates than corresponding films prepared from fresh coacervates. On the basis of the properties of the cast film and its storage stability, the chitosan-alginate-CaCl2 system can be considered for potential membrane coat application. (C) 2001 Wiley-Liss, Inc. and the American Pharmaceutical Association.
    Original languageEnglish
    Pages (from-to)1134-1142
    JournalJournal of Pharmaceutical Sciences
    Issue number8
    Publication statusPublished - 2001


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