Abstract
Background: The role of regulatory T (Treg) cells in allergic predisposition is not known.Objective: This study compared the frequency and function of cord blood Treg cells from nonallergic children (n = 18) with those from children who have egg allergy (n = 15) in the first year of life.Methods: CD4(+) effector T cells and autologous antigen-presenting cells isolated from cord blood mononuclear cells were cocultured with or without CD4(+)CD25(+)CD127(lo/-) Treg cells, and cytokine responses to staphylococcal endotoxin B were assessed after 48 hours.Results: The addition of Treg cell populations to cord blood mononuclear cell cultures resulted in significant reduction in IL-10 (P=.002), IL-13 (P=.012), and IFN-gamma (P
Original language | English |
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Pages (from-to) | "1460-6, 1466 e1-7" |
Journal | Journal of Allergy and Clinical Immunology |
Volume | 121 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2008 |