Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function

Michael Smith; M.R. Tourigny; Paul Noakes; C.A. Thornton; Meri Tulic; Susan Prescott

doi:10.1016/j.jaci.2008.03.025

Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function

Michael Smith, M.R. Tourigny, Paul Noakes, C.A. Thornton, Meri Tulic, Susan Prescott

Research output: Contribution to journal › Article

115 Citations (Scopus)

Abstract

Background: The role of regulatory T (Treg) cells in allergic predisposition is not known.Objective: This study compared the frequency and function of cord blood Treg cells from nonallergic children (n = 18) with those from children who have egg allergy (n = 15) in the first year of life.Methods: CD4(+) effector T cells and autologous antigen-presenting cells isolated from cord blood mononuclear cells were cocultured with or without CD4(+)CD25(+)CD127(lo/-) Treg cells, and cytokine responses to staphylococcal endotoxin B were assessed after 48 hours.Results: The addition of Treg cell populations to cord blood mononuclear cell cultures resulted in significant reduction in IL-10 (P=.002), IL-13 (P=.012), and IFN-gamma (P

Original language	English
Pages (from-to)	"1460-6, 1466 e1-7"
Journal	Journal of Allergy and Clinical Immunology
Volume	121
Issue number	6
DOIs	https://doi.org/10.1016/j.jaci.2008.03.025
Publication status	Published - 2008

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title = "Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function",

abstract = "Background: The role of regulatory T (Treg) cells in allergic predisposition is not known.Objective: This study compared the frequency and function of cord blood Treg cells from nonallergic children (n = 18) with those from children who have egg allergy (n = 15) in the first year of life.Methods: CD4(+) effector T cells and autologous antigen-presenting cells isolated from cord blood mononuclear cells were cocultured with or without CD4(+)CD25(+)CD127(lo/-) Treg cells, and cytokine responses to staphylococcal endotoxin B were assessed after 48 hours.Results: The addition of Treg cell populations to cord blood mononuclear cell cultures resulted in significant reduction in IL-10 (P=.002), IL-13 (P=.012), and IFN-gamma (P",

author = "Michael Smith and M.R. Tourigny and Paul Noakes and C.A. Thornton and Meri Tulic and Susan Prescott",

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journal = "The Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier - Mosby",

number = "6",

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TY - JOUR

T1 - Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function

AU - Smith, Michael

AU - Tourigny, M.R.

AU - Noakes, Paul

AU - Thornton, C.A.

AU - Tulic, Meri

AU - Prescott, Susan

PY - 2008

Y1 - 2008

N2 - Background: The role of regulatory T (Treg) cells in allergic predisposition is not known.Objective: This study compared the frequency and function of cord blood Treg cells from nonallergic children (n = 18) with those from children who have egg allergy (n = 15) in the first year of life.Methods: CD4(+) effector T cells and autologous antigen-presenting cells isolated from cord blood mononuclear cells were cocultured with or without CD4(+)CD25(+)CD127(lo/-) Treg cells, and cytokine responses to staphylococcal endotoxin B were assessed after 48 hours.Results: The addition of Treg cell populations to cord blood mononuclear cell cultures resulted in significant reduction in IL-10 (P=.002), IL-13 (P=.012), and IFN-gamma (P

AB - Background: The role of regulatory T (Treg) cells in allergic predisposition is not known.Objective: This study compared the frequency and function of cord blood Treg cells from nonallergic children (n = 18) with those from children who have egg allergy (n = 15) in the first year of life.Methods: CD4(+) effector T cells and autologous antigen-presenting cells isolated from cord blood mononuclear cells were cocultured with or without CD4(+)CD25(+)CD127(lo/-) Treg cells, and cytokine responses to staphylococcal endotoxin B were assessed after 48 hours.Results: The addition of Treg cell populations to cord blood mononuclear cell cultures resulted in significant reduction in IL-10 (P=.002), IL-13 (P=.012), and IFN-gamma (P

U2 - 10.1016/j.jaci.2008.03.025

DO - 10.1016/j.jaci.2008.03.025

M3 - Article

C2 - 18455222

VL - 121

SP - "1460-6, 1466 e1-7"

JO - The Journal of Allergy and Clinical Immunology

JF - The Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 6

ER -