Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function

Michael Smith, M.R. Tourigny, Paul Noakes, C.A. Thornton, Meri Tulic, Susan Prescott

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Background: The role of regulatory T (Treg) cells in allergic predisposition is not known.Objective: This study compared the frequency and function of cord blood Treg cells from nonallergic children (n = 18) with those from children who have egg allergy (n = 15) in the first year of life.Methods: CD4(+) effector T cells and autologous antigen-presenting cells isolated from cord blood mononuclear cells were cocultured with or without CD4(+)CD25(+)CD127(lo/-) Treg cells, and cytokine responses to staphylococcal endotoxin B were assessed after 48 hours.Results: The addition of Treg cell populations to cord blood mononuclear cell cultures resulted in significant reduction in IL-10 (P=.002), IL-13 (P=.012), and IFN-gamma (P
Original languageEnglish
Pages (from-to)"1460-6, 1466 e1-7"
JournalJournal of Allergy and Clinical Immunology
Volume121
Issue number6
DOIs
Publication statusPublished - 2008

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