Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood

HealthNuts study group

Research output: Contribution to journalArticle

Abstract

Background: We previously reported that infants with Asian-born parents are 3 times more likely to have IgE-mediated food allergy than those with Australian-born parents. It is unknown whether this translates to the increased risk of other allergic diseases later in childhood and whether ancestry interacts with other risk factors for allergic disease development. Objective: To compare prevalence and risk factors for allergic rhinitis, asthma, and aeroallergen sensitization at age 6 between children with East Asian-born and Caucasian-born parents. Methods: A total of 5276 1-year-old infants were recruited into a population-based longitudinal study of allergy. A total of 4455 children participated in age 6 follow-up (84.4%), including 3015 with Caucasian-born parents and 415 with East Asian-born parents. Children underwent skin prick tests to aeroallergens and questionnaires captured data on asthma, eczema, and allergic rhinitis. Results: Compared with children with Caucasian-born parents, children of East Asian-born parents had more allergic rhinitis (19.9% [95% confidence interval (CI) 14.9-26] vs 9.3% [95% CI 8-10.8], P

Original languageEnglish
Pages (from-to)539-547.e3
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume7
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

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Hypersensitivity
Asthma
Parents
Confidence Intervals
Food Hypersensitivity
Eczema
Skin Tests
Immunoglobulin E
Longitudinal Studies
Population
Allergic Rhinitis

Cite this

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title = "Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood",
abstract = "Background: We previously reported that infants with Asian-born parents are 3 times more likely to have IgE-mediated food allergy than those with Australian-born parents. It is unknown whether this translates to the increased risk of other allergic diseases later in childhood and whether ancestry interacts with other risk factors for allergic disease development. Objective: To compare prevalence and risk factors for allergic rhinitis, asthma, and aeroallergen sensitization at age 6 between children with East Asian-born and Caucasian-born parents. Methods: A total of 5276 1-year-old infants were recruited into a population-based longitudinal study of allergy. A total of 4455 children participated in age 6 follow-up (84.4{\%}), including 3015 with Caucasian-born parents and 415 with East Asian-born parents. Children underwent skin prick tests to aeroallergens and questionnaires captured data on asthma, eczema, and allergic rhinitis. Results: Compared with children with Caucasian-born parents, children of East Asian-born parents had more allergic rhinitis (19.9{\%} [95{\%} confidence interval (CI) 14.9-26] vs 9.3{\%} [95{\%} CI 8-10.8], P",
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author = "{HealthNuts study group} and Suaini, {Noor H.A.} and Koplin, {Jennifer J.} and Peters, {Rachel L.} and Mari Sasaki and Ellis, {Justine A.} and Martino, {David J.} and Lowe, {Adrian J.} and Tang, {Mimi L.K.} and Ponsonby, {Anne Louise} and Gurrin, {Lyle C.} and Dharmage, {Shyamali C.} and Allen, {Katrina J.}",
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Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood. / HealthNuts study group.

In: Journal of Allergy and Clinical Immunology: In Practice, Vol. 7, No. 2, 01.02.2019, p. 539-547.e3.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood

AU - HealthNuts study group

AU - Suaini, Noor H.A.

AU - Koplin, Jennifer J.

AU - Peters, Rachel L.

AU - Sasaki, Mari

AU - Ellis, Justine A.

AU - Martino, David J.

AU - Lowe, Adrian J.

AU - Tang, Mimi L.K.

AU - Ponsonby, Anne Louise

AU - Gurrin, Lyle C.

AU - Dharmage, Shyamali C.

AU - Allen, Katrina J.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: We previously reported that infants with Asian-born parents are 3 times more likely to have IgE-mediated food allergy than those with Australian-born parents. It is unknown whether this translates to the increased risk of other allergic diseases later in childhood and whether ancestry interacts with other risk factors for allergic disease development. Objective: To compare prevalence and risk factors for allergic rhinitis, asthma, and aeroallergen sensitization at age 6 between children with East Asian-born and Caucasian-born parents. Methods: A total of 5276 1-year-old infants were recruited into a population-based longitudinal study of allergy. A total of 4455 children participated in age 6 follow-up (84.4%), including 3015 with Caucasian-born parents and 415 with East Asian-born parents. Children underwent skin prick tests to aeroallergens and questionnaires captured data on asthma, eczema, and allergic rhinitis. Results: Compared with children with Caucasian-born parents, children of East Asian-born parents had more allergic rhinitis (19.9% [95% confidence interval (CI) 14.9-26] vs 9.3% [95% CI 8-10.8], P

AB - Background: We previously reported that infants with Asian-born parents are 3 times more likely to have IgE-mediated food allergy than those with Australian-born parents. It is unknown whether this translates to the increased risk of other allergic diseases later in childhood and whether ancestry interacts with other risk factors for allergic disease development. Objective: To compare prevalence and risk factors for allergic rhinitis, asthma, and aeroallergen sensitization at age 6 between children with East Asian-born and Caucasian-born parents. Methods: A total of 5276 1-year-old infants were recruited into a population-based longitudinal study of allergy. A total of 4455 children participated in age 6 follow-up (84.4%), including 3015 with Caucasian-born parents and 415 with East Asian-born parents. Children underwent skin prick tests to aeroallergens and questionnaires captured data on asthma, eczema, and allergic rhinitis. Results: Compared with children with Caucasian-born parents, children of East Asian-born parents had more allergic rhinitis (19.9% [95% confidence interval (CI) 14.9-26] vs 9.3% [95% CI 8-10.8], P

KW - Allergic rhinitis

KW - Ancestry

KW - Asians

KW - Asthma

KW - Children

KW - Eczema

KW - Ethnicity

KW - Food allergy

KW - Hay fever

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DO - 10.1016/j.jaip.2018.07.042

M3 - Article

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SP - 539-547.e3

JO - Journal of Allergy and Clinical Immunology: In Practice

JF - Journal of Allergy and Clinical Immunology: In Practice

SN - 2213-2198

IS - 2

ER -