Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case–control study

Kathryn Greenop, M. Miller, Helen Bailey, Nicholas De Klerk, J. Attia, S.J. Kellie, Carol Bower, B.K. Armstrong, Elizabeth Milne

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Abstract

Purpose: The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this case–control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the risk of CBT were investigated, along with various food groups.
Methods: Cases diagnosed between 2005 and 2010 were identified from 10 pediatric oncology centers in Australia and controls by nationwide random-digit dialling. For study children of ages 3–14 years, diet in the year before diagnosis (or recruitment) was assessed using food frequency questionnaires. Folate intake was adjusted for bioavailability, and dietary micronutrient intake was energy-adjusted. Micronutrients and food groups were analyzed using logistic regression adjusting for relevant confounders. Principal components analysis was conducted to assess food group intake patterns for analysis.
Results: Food and micronutrient data were available for 216 cases and 523 controls. Folate intake was associated with a reduced risk of CBT overall (odds ratio for highest tertile vs. lowest: 0.63, 95 % confidence interval 0.41, 0.97) and particularly low-grade gliomas (odds ratio for highest tertile vs. lowest: 0.52, 95 % confidence interval 0.29, 0.92). Vitamin B6 and B12 intake was not associated with CBT risk, nor was processed meat.
Conclusions: High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood.
Original languageEnglish
Pages (from-to)871-879
JournalCancer Causes and Control
Volume26
Issue number6
Early online date20 Mar 2015
DOIs
Publication statusPublished - Jun 2015

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Folic Acid
Brain Neoplasms
Eating
Micronutrients
Food
Vitamin B 6
Vitamin B 12
Odds Ratio
Confidence Intervals
Diet
Principal Component Analysis
Energy Intake
Glioma
Meat
Biological Availability
Public Health
Logistic Models
Pediatrics

Cite this

@article{da609c25215e455d93c6eeeaab5ba5ad,
title = "Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case–control study",
abstract = "Purpose: The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this case–control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the risk of CBT were investigated, along with various food groups. Methods: Cases diagnosed between 2005 and 2010 were identified from 10 pediatric oncology centers in Australia and controls by nationwide random-digit dialling. For study children of ages 3–14 years, diet in the year before diagnosis (or recruitment) was assessed using food frequency questionnaires. Folate intake was adjusted for bioavailability, and dietary micronutrient intake was energy-adjusted. Micronutrients and food groups were analyzed using logistic regression adjusting for relevant confounders. Principal components analysis was conducted to assess food group intake patterns for analysis. Results: Food and micronutrient data were available for 216 cases and 523 controls. Folate intake was associated with a reduced risk of CBT overall (odds ratio for highest tertile vs. lowest: 0.63, 95 {\%} confidence interval 0.41, 0.97) and particularly low-grade gliomas (odds ratio for highest tertile vs. lowest: 0.52, 95 {\%} confidence interval 0.29, 0.92). Vitamin B6 and B12 intake was not associated with CBT risk, nor was processed meat. Conclusions: High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood.",
author = "Kathryn Greenop and M. Miller and Helen Bailey and {De Klerk}, Nicholas and J. Attia and S.J. Kellie and Carol Bower and B.K. Armstrong and Elizabeth Milne",
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Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case–control study. / Greenop, Kathryn; Miller, M.; Bailey, Helen; De Klerk, Nicholas; Attia, J.; Kellie, S.J.; Bower, Carol; Armstrong, B.K.; Milne, Elizabeth.

In: Cancer Causes and Control, Vol. 26, No. 6, 06.2015, p. 871-879.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case–control study

AU - Greenop, Kathryn

AU - Miller, M.

AU - Bailey, Helen

AU - De Klerk, Nicholas

AU - Attia, J.

AU - Kellie, S.J.

AU - Bower, Carol

AU - Armstrong, B.K.

AU - Milne, Elizabeth

PY - 2015/6

Y1 - 2015/6

N2 - Purpose: The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this case–control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the risk of CBT were investigated, along with various food groups. Methods: Cases diagnosed between 2005 and 2010 were identified from 10 pediatric oncology centers in Australia and controls by nationwide random-digit dialling. For study children of ages 3–14 years, diet in the year before diagnosis (or recruitment) was assessed using food frequency questionnaires. Folate intake was adjusted for bioavailability, and dietary micronutrient intake was energy-adjusted. Micronutrients and food groups were analyzed using logistic regression adjusting for relevant confounders. Principal components analysis was conducted to assess food group intake patterns for analysis. Results: Food and micronutrient data were available for 216 cases and 523 controls. Folate intake was associated with a reduced risk of CBT overall (odds ratio for highest tertile vs. lowest: 0.63, 95 % confidence interval 0.41, 0.97) and particularly low-grade gliomas (odds ratio for highest tertile vs. lowest: 0.52, 95 % confidence interval 0.29, 0.92). Vitamin B6 and B12 intake was not associated with CBT risk, nor was processed meat. Conclusions: High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood.

AB - Purpose: The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this case–control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the risk of CBT were investigated, along with various food groups. Methods: Cases diagnosed between 2005 and 2010 were identified from 10 pediatric oncology centers in Australia and controls by nationwide random-digit dialling. For study children of ages 3–14 years, diet in the year before diagnosis (or recruitment) was assessed using food frequency questionnaires. Folate intake was adjusted for bioavailability, and dietary micronutrient intake was energy-adjusted. Micronutrients and food groups were analyzed using logistic regression adjusting for relevant confounders. Principal components analysis was conducted to assess food group intake patterns for analysis. Results: Food and micronutrient data were available for 216 cases and 523 controls. Folate intake was associated with a reduced risk of CBT overall (odds ratio for highest tertile vs. lowest: 0.63, 95 % confidence interval 0.41, 0.97) and particularly low-grade gliomas (odds ratio for highest tertile vs. lowest: 0.52, 95 % confidence interval 0.29, 0.92). Vitamin B6 and B12 intake was not associated with CBT risk, nor was processed meat. Conclusions: High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood.

U2 - 10.1007/s10552-015-0562-z

DO - 10.1007/s10552-015-0562-z

M3 - Article

VL - 26

SP - 871

EP - 879

JO - Cancer Causes & Control

JF - Cancer Causes & Control

SN - 0957-5243

IS - 6

ER -