Childhood brain tumours, early infections and immune stimulation: A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France)

Judith E. Lupatsch, Helen D. Bailey, Brigitte Lacour, Christelle Dufour, Anne Isabelle Bertozzi, Pierre Leblond, Cécile Faure-Conter, Isabelle Pellier, Claire Freycon, François Doz, Stéphanie Puget, Stéphane Ducassou, Laurent Orsi, Jacqueline Clavel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits and contact with animals. Methods We pooled data from two nationwide French case-control studies, the ESCALE and ESTELLE studies. Children with a CBT diagnosed between 1 and 14 years of age were identified directly from the French National Registry of Childhood Cancers, while population controls were recruited from telephone subscribers. Odds-ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression adjusted for potential confounders. Results The analyses included 469 cases and 2719 controls. We found no association between attending a day-care centre (OR: 0.9, 95%CI: 0.7–1.2) or having had repeated common infections (OR: 0.9, 95%CI: 0.7–1.2) in the first year of life and the risk of CBT. There was also no association with a history of asthma/wheezing (OR: 0.8, 95%CI: 0.56–1.1). Farm visits (OR: 0.6, 95%CI: 0.5–0.8) as well as contact with pets (OR: 0.8, 95%CI: 0.6–1.0) in the first year of life were inversely associated with CBT. Conclusions Our findings suggest a protective effect of early farm visits and contact with pets, but not with other markers of early immune stimulation. This might be related to immune stimulation but needs further investigation.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalCancer Epidemiology
Volume52
DOIs
Publication statusPublished - 1 Feb 2018
Externally publishedYes

Cite this

Lupatsch, Judith E. ; Bailey, Helen D. ; Lacour, Brigitte ; Dufour, Christelle ; Bertozzi, Anne Isabelle ; Leblond, Pierre ; Faure-Conter, Cécile ; Pellier, Isabelle ; Freycon, Claire ; Doz, François ; Puget, Stéphanie ; Ducassou, Stéphane ; Orsi, Laurent ; Clavel, Jacqueline. / Childhood brain tumours, early infections and immune stimulation : A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France). In: Cancer Epidemiology. 2018 ; Vol. 52. pp. 1-9.
@article{92a4c111a5a04f128ef26197a69cd7e1,
title = "Childhood brain tumours, early infections and immune stimulation: A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France)",
abstract = "Background Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits and contact with animals. Methods We pooled data from two nationwide French case-control studies, the ESCALE and ESTELLE studies. Children with a CBT diagnosed between 1 and 14 years of age were identified directly from the French National Registry of Childhood Cancers, while population controls were recruited from telephone subscribers. Odds-ratios (OR) and 95{\%} confidence intervals (CI) were estimated using logistic regression adjusted for potential confounders. Results The analyses included 469 cases and 2719 controls. We found no association between attending a day-care centre (OR: 0.9, 95{\%}CI: 0.7–1.2) or having had repeated common infections (OR: 0.9, 95{\%}CI: 0.7–1.2) in the first year of life and the risk of CBT. There was also no association with a history of asthma/wheezing (OR: 0.8, 95{\%}CI: 0.56–1.1). Farm visits (OR: 0.6, 95{\%}CI: 0.5–0.8) as well as contact with pets (OR: 0.8, 95{\%}CI: 0.6–1.0) in the first year of life were inversely associated with CBT. Conclusions Our findings suggest a protective effect of early farm visits and contact with pets, but not with other markers of early immune stimulation. This might be related to immune stimulation but needs further investigation.",
keywords = "Children, Central nervous system tumours, Brain tumours, Risk factors, Day-care, Infections, Atopy, Allergies, Farm, Animals, Case control study, NERVOUS-SYSTEM TUMORS, CONTROL-STUDY CEFALO, RESPIRATORY-INFECTIONS, CARE ATTENDANCE, BIRTH CHARACTERISTICS, CHILDREN ANALYSIS, RISK-FACTORS, EARLY-LIFE, CANCER, EXPOSURE",
author = "Lupatsch, {Judith E.} and Bailey, {Helen D.} and Brigitte Lacour and Christelle Dufour and Bertozzi, {Anne Isabelle} and Pierre Leblond and C{\'e}cile Faure-Conter and Isabelle Pellier and Claire Freycon and Fran{\cc}ois Doz and St{\'e}phanie Puget and St{\'e}phane Ducassou and Laurent Orsi and Jacqueline Clavel",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.canep.2017.10.015",
language = "English",
volume = "52",
pages = "1--9",
journal = "Cancer Detection and Prevention",
issn = "0361-090X",
publisher = "Elsevier",

}

Lupatsch, JE, Bailey, HD, Lacour, B, Dufour, C, Bertozzi, AI, Leblond, P, Faure-Conter, C, Pellier, I, Freycon, C, Doz, F, Puget, S, Ducassou, S, Orsi, L & Clavel, J 2018, 'Childhood brain tumours, early infections and immune stimulation: A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France)' Cancer Epidemiology, vol. 52, pp. 1-9. https://doi.org/10.1016/j.canep.2017.10.015

Childhood brain tumours, early infections and immune stimulation : A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France). / Lupatsch, Judith E.; Bailey, Helen D.; Lacour, Brigitte; Dufour, Christelle; Bertozzi, Anne Isabelle; Leblond, Pierre; Faure-Conter, Cécile; Pellier, Isabelle; Freycon, Claire; Doz, François; Puget, Stéphanie; Ducassou, Stéphane; Orsi, Laurent; Clavel, Jacqueline.

In: Cancer Epidemiology, Vol. 52, 01.02.2018, p. 1-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Childhood brain tumours, early infections and immune stimulation

T2 - A pooled analysis of the ESCALE and ESTELLE case-control studies (SFCE, France)

AU - Lupatsch, Judith E.

AU - Bailey, Helen D.

AU - Lacour, Brigitte

AU - Dufour, Christelle

AU - Bertozzi, Anne Isabelle

AU - Leblond, Pierre

AU - Faure-Conter, Cécile

AU - Pellier, Isabelle

AU - Freycon, Claire

AU - Doz, François

AU - Puget, Stéphanie

AU - Ducassou, Stéphane

AU - Orsi, Laurent

AU - Clavel, Jacqueline

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits and contact with animals. Methods We pooled data from two nationwide French case-control studies, the ESCALE and ESTELLE studies. Children with a CBT diagnosed between 1 and 14 years of age were identified directly from the French National Registry of Childhood Cancers, while population controls were recruited from telephone subscribers. Odds-ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression adjusted for potential confounders. Results The analyses included 469 cases and 2719 controls. We found no association between attending a day-care centre (OR: 0.9, 95%CI: 0.7–1.2) or having had repeated common infections (OR: 0.9, 95%CI: 0.7–1.2) in the first year of life and the risk of CBT. There was also no association with a history of asthma/wheezing (OR: 0.8, 95%CI: 0.56–1.1). Farm visits (OR: 0.6, 95%CI: 0.5–0.8) as well as contact with pets (OR: 0.8, 95%CI: 0.6–1.0) in the first year of life were inversely associated with CBT. Conclusions Our findings suggest a protective effect of early farm visits and contact with pets, but not with other markers of early immune stimulation. This might be related to immune stimulation but needs further investigation.

AB - Background Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits and contact with animals. Methods We pooled data from two nationwide French case-control studies, the ESCALE and ESTELLE studies. Children with a CBT diagnosed between 1 and 14 years of age were identified directly from the French National Registry of Childhood Cancers, while population controls were recruited from telephone subscribers. Odds-ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression adjusted for potential confounders. Results The analyses included 469 cases and 2719 controls. We found no association between attending a day-care centre (OR: 0.9, 95%CI: 0.7–1.2) or having had repeated common infections (OR: 0.9, 95%CI: 0.7–1.2) in the first year of life and the risk of CBT. There was also no association with a history of asthma/wheezing (OR: 0.8, 95%CI: 0.56–1.1). Farm visits (OR: 0.6, 95%CI: 0.5–0.8) as well as contact with pets (OR: 0.8, 95%CI: 0.6–1.0) in the first year of life were inversely associated with CBT. Conclusions Our findings suggest a protective effect of early farm visits and contact with pets, but not with other markers of early immune stimulation. This might be related to immune stimulation but needs further investigation.

KW - Children

KW - Central nervous system tumours

KW - Brain tumours

KW - Risk factors

KW - Day-care

KW - Infections

KW - Atopy

KW - Allergies

KW - Farm

KW - Animals

KW - Case control study

KW - NERVOUS-SYSTEM TUMORS

KW - CONTROL-STUDY CEFALO

KW - RESPIRATORY-INFECTIONS

KW - CARE ATTENDANCE

KW - BIRTH CHARACTERISTICS

KW - CHILDREN ANALYSIS

KW - RISK-FACTORS

KW - EARLY-LIFE

KW - CANCER

KW - EXPOSURE

UR - http://www.scopus.com/inward/record.url?scp=85033377724&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2017.10.015

DO - 10.1016/j.canep.2017.10.015

M3 - Article

VL - 52

SP - 1

EP - 9

JO - Cancer Detection and Prevention

JF - Cancer Detection and Prevention

SN - 0361-090X

ER -