Chief cell-predominant gastric polyps: A series of 12 cases with literature review

K. Chan, I.S. Brown, T. Kyle, G.Y. Lauwers, Priyanthi Kumarasinghe

    Research output: Contribution to journalArticlepeer-review

    34 Citations (Scopus)

    Abstract

    © 2016 John Wiley & Sons Ltd. Aims: Rare gastric lesions composed of a combined proliferation of chief and oxyntic cells have been variably called adenocarcinoma of fundic gland type and oxyntic gland polyp/adenoma. Herein, we present a series of cases that show a morphological spectrum of chief and oxyntic cell proliferations. Methods and results: Routine and consultation cases were collated from five institutions. Information regarding site, size, endoscopic appearance, clinical history and medication use, when available, was accrued, as was the histological features and immunoprofiles. A total of 12 cases were collated. Age ranged from 39 to 81 years. All the lesions were located in the fundus; seven of eight were polypoid lesions endoscopically. Lesions were primarily solitary, averaged 4.6 mm in diameter (largest 9 mm) and comprised >50% chief cells. The predominant architectural pattern was of anastomosing and solid and clustered glands or a mixture of these patterns. Lesions were limited mainly to the mucosa, although two showed submucosal involvement. None had known metastatic disease. Conclusions: This series included lesions that were previously described as gastric adenocarcinoma of fundic gland type and oxyntic gland polyp/adenoma. They are located exclusively in the fundus and composed predominantly of chief cells with low-grade cytology and appear to show a morphological continuum.
    Original languageEnglish
    Pages (from-to)825-833
    Number of pages9
    JournalHistopathology
    Volume68
    Issue number6
    DOIs
    Publication statusPublished - 1 May 2016

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