Chemotherapy and immunotherapy: Mapping the road ahead

    Research output: Contribution to journalReview article

    72 Citations (Scopus)

    Abstract

    © 2015 Elsevier Ltd. Cancer immunotherapy, and in particular checkpoint blockade, is now standard clinical care for a growing number of cancers. Cytotoxic drugs have been the primary weapon against cancer for a long time and have typically been understood because of their capacity to directly kill tumour cells. It is now clear that these drugs are potential partners for checkpoint blockade and different drugs can influence the immune response to cancer through a wide variety of mechanisms. Some of these relate to immunogenic cell death, whilst others relate to changes in antigen-presentation, tumour cell targeting, or depletion of immunosuppressive cells. Here, we review some recent advances in our understanding of the immunological changes associated with chemotherapy, discuss progress in combining chemotherapy with checkpoint blockade, and comment on the difficulties encountered in translating promising preclinical data into successful treatments for cancer patients.
    Original languageEnglish
    Pages (from-to)23-29
    Number of pages7
    JournalCurrent Opinion in Immunology
    Volume39
    DOIs
    Publication statusPublished - 2016

    Fingerprint

    Dive into the research topics of 'Chemotherapy and immunotherapy: Mapping the road ahead'. Together they form a unique fingerprint.

    Cite this