Chemo-Immunotherapy: Exploiting the Immunogenic Potential of Chemotherapy in Thoracic Cancer

Wayne Aston

Research output: Thesis › Doctoral Thesis

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Abstract

Chemotherapy is used in many cancers. Although many patients display some clinical response, it is often not curative. Selected chemotherapeutics have been previously found to have immune-stimulating properties via various biological mechanisms. With immunotherapy recently showing promising results in some cancers, the next logical step would be to combine the two treatment modalities. However, it is not known how chemotherapy and immunotherapy can be most effectively combined in order to achieve synergy. In this thesis, I explored the potential for combining chemotherapy and immunotherapy, optimising preclinical models, testing the effects of co-medication and identifying the most optimal drug combinations.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date20 Sep 2019
DOIs
Publication statusUnpublished - 2019

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Immunotherapy
Thorax
Drug Therapy
Neoplasms
Drug Combinations
Therapeutics

Cite this

Aston, Wayne. / Chemo-Immunotherapy: Exploiting the Immunogenic Potential of Chemotherapy in Thoracic Cancer. 2019.
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title = "Chemo-Immunotherapy: Exploiting the Immunogenic Potential of Chemotherapy in Thoracic Cancer",
abstract = "Chemotherapy is used in many cancers. Although many patients display some clinical response, it is often not curative. Selected chemotherapeutics have been previously found to have immune-stimulating properties via various biological mechanisms. With immunotherapy recently showing promising results in some cancers, the next logical step would be to combine the two treatment modalities. However, it is not known how chemotherapy and immunotherapy can be most effectively combined in order to achieve synergy. In this thesis, I explored the potential for combining chemotherapy and immunotherapy, optimising preclinical models, testing the effects of co-medication and identifying the most optimal drug combinations.",
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Aston, W 2019, 'Chemo-Immunotherapy: Exploiting the Immunogenic Potential of Chemotherapy in Thoracic Cancer', Doctor of Philosophy, The University of Western Australia. https://doi.org/10.26182/5dbf70a56c6b0

Chemo-Immunotherapy: Exploiting the Immunogenic Potential of Chemotherapy in Thoracic Cancer. / Aston, Wayne.

2019.

Research output: Thesis › Doctoral Thesis

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AB - Chemotherapy is used in many cancers. Although many patients display some clinical response, it is often not curative. Selected chemotherapeutics have been previously found to have immune-stimulating properties via various biological mechanisms. With immunotherapy recently showing promising results in some cancers, the next logical step would be to combine the two treatment modalities. However, it is not known how chemotherapy and immunotherapy can be most effectively combined in order to achieve synergy. In this thesis, I explored the potential for combining chemotherapy and immunotherapy, optimising preclinical models, testing the effects of co-medication and identifying the most optimal drug combinations.

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Aston W. Chemo-Immunotherapy: Exploiting the Immunogenic Potential of Chemotherapy in Thoracic Cancer. 2019. https://doi.org/10.26182/5dbf70a56c6b0

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  • THESIS - DOCTOR OF PHILOSOPHY - ASTON Wayne John - 2019

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