TY - JOUR
T1 - Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118
AU - Shang, Zhuo
AU - Li, Xiaoming
AU - Meng, Li
AU - Li, Chunshun
AU - Gao, Shushan
AU - Huang, Caiguo
AU - Wang, Bingui
PY - 2012
Y1 - 2012
N2 - Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118, a fungus obtained from a deep-sea sediment sample, resulted in the isolation of a known antibacterial compound, xanthocillin X (1), and 14 other known compounds comprising three steroids (2-4), two ceramides (5 and 6), six aromatic compounds (7-12), and three alkaloids (13-15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay, xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli, and significant cytotoxicity against MCF-7, HepG2, H460, Hela, Du145, and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2, Hela, Du145, and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1).
AB - Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118, a fungus obtained from a deep-sea sediment sample, resulted in the isolation of a known antibacterial compound, xanthocillin X (1), and 14 other known compounds comprising three steroids (2-4), two ceramides (5 and 6), six aromatic compounds (7-12), and three alkaloids (13-15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay, xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli, and significant cytotoxicity against MCF-7, HepG2, H460, Hela, Du145, and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2, Hela, Du145, and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1).
KW - antibacterial activity
KW - bioguided isolation
KW - cytotoxicity
KW - deep-sea sediment-derived fungus
KW - Penicillium commune
KW - xanthocillin X
UR - http://www.scopus.com/inward/record.url?scp=84863498024&partnerID=8YFLogxK
U2 - 10.1007/s00343-012-1075-1
DO - 10.1007/s00343-012-1075-1
M3 - Article
AN - SCOPUS:84863498024
VL - 30
SP - 305
EP - 314
JO - Chinese Journal of Oceanology and Limnology
JF - Chinese Journal of Oceanology and Limnology
SN - 0254-4059
IS - 2
ER -