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Abstract
A biosynthetic gene cluster that is significantly upregulated in the fungal wheat pathogen Parastagonospora nodorum during plant infection was reconstructed heterologously in Aspergillus nidulans. This led to the discovery of five new α-pyrone polyketides, alternapyrones B-F (2-6). Compounds 5 and 6, which contain a highly substituted dihydrofuran, exhibited phytotoxicity on wheat seed germination. It is demonstrated that only three enzymes, one highly reducing polyketide synthase and two multifunctional P450 oxygenases, are needed to synthesize the structurally complex products.
Original language | English |
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Pages (from-to) | 6148-6152 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 20 |
Issue number | 19 |
DOIs | |
Publication status | Published - 5 Oct 2018 |
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Dive into the research topics of 'Chemical Ecogenomics-Guided Discovery of Phytotoxic α-Pyrones from the Fungal Wheat Pathogen Parastagonospora nodorum'. Together they form a unique fingerprint.Projects
- 1 Finished
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Two new phytotoxins in Septoria nodorum blotch: Biosynthesis and functions
Chooi, H., Solomon, P. & Tang, Y.
1/01/17 → 31/12/19
Project: Research