Chemical and biological investigations into the major secondary metabolites isolated from marine sponges of the Western Australian coast

Samuele Sala

doi:10.26182/e75c-s056

Chemical and biological investigations into the major secondary metabolites isolated from marine sponges of the Western Australian coast

Samuele Sala

School of Molecular Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

The following thesis details the isolation and structural elucidation of 22 secondary metabolites,
reported from natural sources for the first time, as well as the isolation of 18 known secondary
metabolites, from marine sponges of six disparate genera: Mycale (Chapter 2), Crella (Chapter 3),
Clathria (Chapter 4), Dendrilla (Chapter 5), Isabela (Chapter 6) and Sceptrella (Chapter 7).
Structures of all metabolites were elucidated spectroscopically, and where practicable, by
crystallographic methods, or with the assistance of computational chemistry methods.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Stewart, Scott, Supervisor Flematti, Gavin, Supervisor Yeoh, George, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	12 Oct 2023
DOIs	https://doi.org/10.26182/e75c-s056
Publication status	Unpublished - 2023

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.26182/e75c-s056

THESIS - DOCTOR OF PHILOSOPHY - SALA Samuele - 2023
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4 Article
1 Review article

Dendrillic Acids A and B: Nitrogenous, Rearranged Spongian Nor-Diterpenes from a Dendrilla sp. Marine Sponge
Sala, S., James, P. J. C., Nealon, G. L., Fromont, J., Gomez, O., Vuong, D., Lacey, E. & Flematti, G. R., 24 Mar 2023, In: Journal of Natural Products. 86, 3, p. 482-489 8 p.
Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus)
Marine Natural Products from Flora and Fauna of the Western Australian Coast: Taxonomy, Isolation and Biological Activity
Sala, S., Micke, S. K. & Flematti, G. R., Feb 2023, In: Molecules. 28, 3, 1452.
Research output: Contribution to journal › Review article › peer-review

Open Access
Type-I Hemins and Free Porphyrins from a Western Australian Sponge Isabela sp.
Sala, S., Moggach, S. A., Nealon, G. L., Fromont, J., Gomez, O., Vuong, D., Lacey, E. & Flematti, G. R., Jan 2023, In: Marine Drugs. 21, 1, 41.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Citations (Web of Science)

Cite this

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title = "Chemical and biological investigations into the major secondary metabolites isolated from marine sponges of the Western Australian coast",

abstract = "The following thesis details the isolation and structural elucidation of 22 secondary metabolites,reported from natural sources for the first time, as well as the isolation of 18 known secondarymetabolites, from marine sponges of six disparate genera: Mycale (Chapter 2), Crella (Chapter 3),Clathria (Chapter 4), Dendrilla (Chapter 5), Isabela (Chapter 6) and Sceptrella (Chapter 7).Structures of all metabolites were elucidated spectroscopically, and where practicable, bycrystallographic methods, or with the assistance of computational chemistry methods.",

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school = "The University of Western Australia",

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AB - The following thesis details the isolation and structural elucidation of 22 secondary metabolites,reported from natural sources for the first time, as well as the isolation of 18 known secondarymetabolites, from marine sponges of six disparate genera: Mycale (Chapter 2), Crella (Chapter 3),Clathria (Chapter 4), Dendrilla (Chapter 5), Isabela (Chapter 6) and Sceptrella (Chapter 7).Structures of all metabolites were elucidated spectroscopically, and where practicable, bycrystallographic methods, or with the assistance of computational chemistry methods.

KW - Natural Products

KW - Porifera

KW - NMR

KW - LC-MS

KW - HPLC

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M3 - Doctoral Thesis

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Chemical and biological investigations into the major secondary metabolites isolated from marine sponges of the Western Australian coast

Abstract

UN SDGs

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Dendrillic Acids A and B: Nitrogenous, Rearranged Spongian Nor-Diterpenes from a Dendrilla sp. Marine Sponge

Marine Natural Products from Flora and Fauna of the Western Australian Coast: Taxonomy, Isolation and Biological Activity

Type-I Hemins and Free Porphyrins from a Western Australian Sponge Isabela sp.

Cite this