Characterization of the Acute Clinical Illness Associated With Human Immunodeficiency Virus Infection

Sydney AIDS Study Group

Research output: Contribution to journalArticlepeer-review

208 Citations (Scopus)


The clinical and serologic features and immune status of 39 homosexual men who had seroconversion to human immunodeficiency virus positivity were compared with 26 homosexual men who remained seronegative during a six-month period. An acute clinical Illness occurred in 92.3% of seroconverted subjects and 40% of controls. The duration of illness was significantly greater In the seroconverters than the controls (10 + 4.4 days). A general practitioner was consulted by 87.2% of the seroconverters because of the illness, including 12.8% who were admitted to hospital, compared with 20% of controls. The most frequently reported symptoms In the seroconversion group were fever (76.9%); lethargy and malaise (66.7%); anorexia, sore throat, and myalgias (56.4% each); headaches and arthralgias (48.7% each); weight loss (46.2%); swollen glands (43.5%); retro-orbital pain (38.5%); and dehydration and nausea (30.8% each). Lymphadenopathy developed in 75% of seroconverters compared with 4% of controls. Changes in T-cell subsets were not found in controls, but the number of T4 + cells and the T4 + /T8 + ratio decreased significantly in seroconverters.

Original languageEnglish
Pages (from-to)945-949
Number of pages5
JournalArchives of Internal Medicine
Issue number4
Publication statusPublished - Apr 1988


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