CHARACTERIZATION OF AN SHV-5 RELATED EXTENDED BROAD-SPECTRUM BETA-LACTAMASE IN ENTEROBACTERIACEAE FROM WESTERN AUSTRALIA

L. Mulgrave; Paul Attwood

doi:10.3109/00313029309068906

CHARACTERIZATION OF AN SHV-5 RELATED EXTENDED BROAD-SPECTRUM BETA-LACTAMASE IN ENTEROBACTERIACEAE FROM WESTERN AUSTRALIA

L. Mulgrave, Paul Attwood

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

31 Citations (Web of Science)

Abstract

Among 209 isolates of aminoglycoside resistant Enterobacteriaceae isolated from patients attending the Sir Charles Gairdner Hospital in Perth, Western Australia between January 1985 and June 1991, 41 strains demonstrated additional resistance to cefotaxime, ceftriaxone, ceftazidime and aztreonam. Significant synergy was demonstrable between these beta-lactams and clavulanic acid against resistant strains. The beta-lactamase was mediated by a 170 Kb self-transferring plasmid and identified as the SHV-5 type in isoelectric focusing (pl 8.2) and substrate hydrolysis kinetic studies. The findings record the introduction of extended broad-spectrum beta-lactamases to Australia.

Original language	English
Pages (from-to)	71-75
Journal	Pathology
Volume	25
DOIs	https://doi.org/10.3109/00313029309068906
Publication status	Published - 1993

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title = "CHARACTERIZATION OF AN SHV-5 RELATED EXTENDED BROAD-SPECTRUM BETA-LACTAMASE IN ENTEROBACTERIACEAE FROM WESTERN AUSTRALIA",

abstract = "Among 209 isolates of aminoglycoside resistant Enterobacteriaceae isolated from patients attending the Sir Charles Gairdner Hospital in Perth, Western Australia between January 1985 and June 1991, 41 strains demonstrated additional resistance to cefotaxime, ceftriaxone, ceftazidime and aztreonam. Significant synergy was demonstrable between these beta-lactams and clavulanic acid against resistant strains. The beta-lactamase was mediated by a 170 Kb self-transferring plasmid and identified as the SHV-5 type in isoelectric focusing (pl 8.2) and substrate hydrolysis kinetic studies. The findings record the introduction of extended broad-spectrum beta-lactamases to Australia.",

author = "L. Mulgrave and Paul Attwood",

year = "1993",

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language = "English",

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AU - Attwood, Paul

PY - 1993

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N2 - Among 209 isolates of aminoglycoside resistant Enterobacteriaceae isolated from patients attending the Sir Charles Gairdner Hospital in Perth, Western Australia between January 1985 and June 1991, 41 strains demonstrated additional resistance to cefotaxime, ceftriaxone, ceftazidime and aztreonam. Significant synergy was demonstrable between these beta-lactams and clavulanic acid against resistant strains. The beta-lactamase was mediated by a 170 Kb self-transferring plasmid and identified as the SHV-5 type in isoelectric focusing (pl 8.2) and substrate hydrolysis kinetic studies. The findings record the introduction of extended broad-spectrum beta-lactamases to Australia.

AB - Among 209 isolates of aminoglycoside resistant Enterobacteriaceae isolated from patients attending the Sir Charles Gairdner Hospital in Perth, Western Australia between January 1985 and June 1991, 41 strains demonstrated additional resistance to cefotaxime, ceftriaxone, ceftazidime and aztreonam. Significant synergy was demonstrable between these beta-lactams and clavulanic acid against resistant strains. The beta-lactamase was mediated by a 170 Kb self-transferring plasmid and identified as the SHV-5 type in isoelectric focusing (pl 8.2) and substrate hydrolysis kinetic studies. The findings record the introduction of extended broad-spectrum beta-lactamases to Australia.

U2 - 10.3109/00313029309068906

DO - 10.3109/00313029309068906

M3 - Article

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JO - Pathology

JF - Pathology

ER -

CHARACTERIZATION OF AN SHV-5 RELATED EXTENDED BROAD-SPECTRUM BETA-LACTAMASE IN ENTEROBACTERIACEAE FROM WESTERN AUSTRALIA

Abstract

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