Abstract
Background: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension. Research Design and Methods: Children and adolescents with type 1 diabetes used the Medtronic MiniMed (TM) 640G pump as part of a randomized controlled trial. Data collected on a subgroup of participants on PLGM (suspend before low enabled) from CareLink (R) Therapy Management Software were analyzed to explore the time and duration of PLGM-initiated pump suspension. Day and nighttime were defined as 06:00 am to 10:00 pm and 10:00 pm to 6:00 am, respectively. Results: There were 20,183 suspend before low events in 8523 days (2.37 events/day). The mean suspend duration was 55.0 +/- 32.7 min (day 50.0 +/- 30.1, night 71.7 +/- 35.1; P <0.001). Although a 2-h pump suspension was more frequent at night (day 5%, night 18%), a patient-initiated resumption occurred more during day (day 34%, night 12%). SG values did not reach
| Original language | English |
|---|---|
| Pages (from-to) | 28-34 |
| Number of pages | 7 |
| Journal | Diabetes Technology & Therapeutics |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
| Event | Conference of the Australian-Pediatric-Endocrine-Group (APEG) (2017) - The Hotel Grand Chancellor, Hobart, Australia Duration: 26 Nov 2017 → 29 Nov 2017 https://willorganise.eventsair.com/QuickEventWebsitePortal/2017-apeg-asm/website |
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Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management System. / PLGM Study Grp.
In: Diabetes Technology & Therapeutics, Vol. 21, No. 1, 01.01.2019, p. 28-34.Research output: Contribution to journal › Article
TY - JOUR
T1 - Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management System
AU - PLGM Study Grp
AU - Abraham, Mary B.
AU - Smith, Grant J.
AU - Nicholas, Jennifer A.
AU - Fairchild, Janice M.
AU - King, Bruce R.
AU - Ambler, Geoffrey R.
AU - Cameron, Fergus J.
AU - Davis, Elizabeth A.
AU - Jones, Timothy W.
AU - Klimek, Westmead-Julie
AU - Heels, Kristine
AU - Jopling, Tracey
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension. Research Design and Methods: Children and adolescents with type 1 diabetes used the Medtronic MiniMed (TM) 640G pump as part of a randomized controlled trial. Data collected on a subgroup of participants on PLGM (suspend before low enabled) from CareLink (R) Therapy Management Software were analyzed to explore the time and duration of PLGM-initiated pump suspension. Day and nighttime were defined as 06:00 am to 10:00 pm and 10:00 pm to 6:00 am, respectively. Results: There were 20,183 suspend before low events in 8523 days (2.37 events/day). The mean suspend duration was 55.0 +/- 32.7 min (day 50.0 +/- 30.1, night 71.7 +/- 35.1; P <0.001). Although a 2-h pump suspension was more frequent at night (day 5%, night 18%), a patient-initiated resumption occurred more during day (day 34%, night 12%). SG values did not reach
AB - Background: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension. Research Design and Methods: Children and adolescents with type 1 diabetes used the Medtronic MiniMed (TM) 640G pump as part of a randomized controlled trial. Data collected on a subgroup of participants on PLGM (suspend before low enabled) from CareLink (R) Therapy Management Software were analyzed to explore the time and duration of PLGM-initiated pump suspension. Day and nighttime were defined as 06:00 am to 10:00 pm and 10:00 pm to 6:00 am, respectively. Results: There were 20,183 suspend before low events in 8523 days (2.37 events/day). The mean suspend duration was 55.0 +/- 32.7 min (day 50.0 +/- 30.1, night 71.7 +/- 35.1; P <0.001). Although a 2-h pump suspension was more frequent at night (day 5%, night 18%), a patient-initiated resumption occurred more during day (day 34%, night 12%). SG values did not reach
KW - Predictive Low-Glucose Management
KW - Type 1 diabetes
KW - Suspend before low
KW - Sensor glucose
KW - INDUCED HYPOGLYCEMIA
KW - PUMP THERAPY
KW - REDUCTION
KW - ADOLESCENTS
KW - PREVENTION
KW - ALGORITHM
U2 - 10.1089/dia.2018.0205
DO - 10.1089/dia.2018.0205
M3 - Article
VL - 21
SP - 28
EP - 34
JO - Diabetes Technology & Therapeutics
JF - Diabetes Technology & Therapeutics
SN - 1557-8593
IS - 1
ER -