Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management System

PLGM Study Grp

Research output: Contribution to journalArticle

Abstract

Background: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension. Research Design and Methods: Children and adolescents with type 1 diabetes used the Medtronic MiniMed (TM) 640G pump as part of a randomized controlled trial. Data collected on a subgroup of participants on PLGM (suspend before low enabled) from CareLink (R) Therapy Management Software were analyzed to explore the time and duration of PLGM-initiated pump suspension. Day and nighttime were defined as 06:00 am to 10:00 pm and 10:00 pm to 6:00 am, respectively. Results: There were 20,183 suspend before low events in 8523 days (2.37 events/day). The mean suspend duration was 55.0 +/- 32.7 min (day 50.0 +/- 30.1, night 71.7 +/- 35.1; P <0.001). Although a 2-h pump suspension was more frequent at night (day 5%, night 18%), a patient-initiated resumption occurred more during day (day 34%, night 12%). SG values did not reach

Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalDiabetes Technology & Therapeutics
Volume21
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019
EventConference of the Australian-Pediatric-Endocrine-Group (APEG) (2017) - The Hotel Grand Chancellor, Hobart, Australia
Duration: 26 Nov 201729 Nov 2017
https://willorganise.eventsair.com/QuickEventWebsitePortal/2017-apeg-asm/website

Cite this

@article{7f60bd7593c242419fdc3549844d8c9d,
title = "Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management System",
abstract = "Background: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension. Research Design and Methods: Children and adolescents with type 1 diabetes used the Medtronic MiniMed (TM) 640G pump as part of a randomized controlled trial. Data collected on a subgroup of participants on PLGM (suspend before low enabled) from CareLink (R) Therapy Management Software were analyzed to explore the time and duration of PLGM-initiated pump suspension. Day and nighttime were defined as 06:00 am to 10:00 pm and 10:00 pm to 6:00 am, respectively. Results: There were 20,183 suspend before low events in 8523 days (2.37 events/day). The mean suspend duration was 55.0 +/- 32.7 min (day 50.0 +/- 30.1, night 71.7 +/- 35.1; P <0.001). Although a 2-h pump suspension was more frequent at night (day 5{\%}, night 18{\%}), a patient-initiated resumption occurred more during day (day 34{\%}, night 12{\%}). SG values did not reach",
keywords = "Predictive Low-Glucose Management, Type 1 diabetes, Suspend before low, Sensor glucose, INDUCED HYPOGLYCEMIA, PUMP THERAPY, REDUCTION, ADOLESCENTS, PREVENTION, ALGORITHM",
author = "{PLGM Study Grp} and Abraham, {Mary B.} and Smith, {Grant J.} and Nicholas, {Jennifer A.} and Fairchild, {Janice M.} and King, {Bruce R.} and Ambler, {Geoffrey R.} and Cameron, {Fergus J.} and Davis, {Elizabeth A.} and Jones, {Timothy W.} and Westmead-Julie Klimek and Kristine Heels and Tracey Jopling",
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language = "English",
volume = "21",
pages = "28--34",
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Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management System. / PLGM Study Grp.

In: Diabetes Technology & Therapeutics, Vol. 21, No. 1, 01.01.2019, p. 28-34.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management System

AU - PLGM Study Grp

AU - Abraham, Mary B.

AU - Smith, Grant J.

AU - Nicholas, Jennifer A.

AU - Fairchild, Janice M.

AU - King, Bruce R.

AU - Ambler, Geoffrey R.

AU - Cameron, Fergus J.

AU - Davis, Elizabeth A.

AU - Jones, Timothy W.

AU - Klimek, Westmead-Julie

AU - Heels, Kristine

AU - Jopling, Tracey

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension. Research Design and Methods: Children and adolescents with type 1 diabetes used the Medtronic MiniMed (TM) 640G pump as part of a randomized controlled trial. Data collected on a subgroup of participants on PLGM (suspend before low enabled) from CareLink (R) Therapy Management Software were analyzed to explore the time and duration of PLGM-initiated pump suspension. Day and nighttime were defined as 06:00 am to 10:00 pm and 10:00 pm to 6:00 am, respectively. Results: There were 20,183 suspend before low events in 8523 days (2.37 events/day). The mean suspend duration was 55.0 +/- 32.7 min (day 50.0 +/- 30.1, night 71.7 +/- 35.1; P <0.001). Although a 2-h pump suspension was more frequent at night (day 5%, night 18%), a patient-initiated resumption occurred more during day (day 34%, night 12%). SG values did not reach

AB - Background: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension. Research Design and Methods: Children and adolescents with type 1 diabetes used the Medtronic MiniMed (TM) 640G pump as part of a randomized controlled trial. Data collected on a subgroup of participants on PLGM (suspend before low enabled) from CareLink (R) Therapy Management Software were analyzed to explore the time and duration of PLGM-initiated pump suspension. Day and nighttime were defined as 06:00 am to 10:00 pm and 10:00 pm to 6:00 am, respectively. Results: There were 20,183 suspend before low events in 8523 days (2.37 events/day). The mean suspend duration was 55.0 +/- 32.7 min (day 50.0 +/- 30.1, night 71.7 +/- 35.1; P <0.001). Although a 2-h pump suspension was more frequent at night (day 5%, night 18%), a patient-initiated resumption occurred more during day (day 34%, night 12%). SG values did not reach

KW - Predictive Low-Glucose Management

KW - Type 1 diabetes

KW - Suspend before low

KW - Sensor glucose

KW - INDUCED HYPOGLYCEMIA

KW - PUMP THERAPY

KW - REDUCTION

KW - ADOLESCENTS

KW - PREVENTION

KW - ALGORITHM

U2 - 10.1089/dia.2018.0205

DO - 10.1089/dia.2018.0205

M3 - Article

VL - 21

SP - 28

EP - 34

JO - Diabetes Technology & Therapeutics

JF - Diabetes Technology & Therapeutics

SN - 1557-8593

IS - 1

ER -