Characterising the effects of human amnion epithelial cells and their secretome on the liver progenitor cell response

Neil Andrewartha

Research output: ThesisDoctoral Thesis

34 Downloads (Pure)

Abstract

Human amnion epithelial cells (hAECs) are reported to alleviate inflammation and fibrosis when transplanted into animal models of liver disease. However, the mechanisms underlying the therapeutic efficacy of hAECs, particularly, how they affect liver regeneration are not fully understood. Liver regeneration during chronic liver injury is assisted by activation of the liver progenitor cell response. This thesis examines the interaction between hAECs and LPCs in vivo and in vitro. The data presented provides compelling evidence that hAECs promote LPC proliferation, migration and differentiation by paracrine signalling and crucially, it establishes mechanisms governing these effects.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date8 Apr 2020
DOIs
Publication statusUnpublished - 2019

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