Characterising and improving image quality in optical coherence tomography and elastography by means of optical beam shaping and simulations

    Research output: ThesisDoctoral Thesis

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    Abstract

    One path to understanding the genesis and progression of disease, and to early disease detection, lies in the advancement of label-free microscopy techniques, such as optical coherence tomography (OCT) and optical coherence elastography (OCE). To this end, this thesis describes the methods used to alter and improve OCT and OCE image quality via beam shaping; to compare it in realistic and controlled turbid tissue scenarios using novel phantoms; and to analyse it with the aid of simulations. With these tools, we characterise the influence of Bessel beams on contrast in OCT, and demonstrate a substantial resolution improvement in ultrahigh-resolution OCE.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date12 Jan 2017
    Publication statusUnpublished - 2017

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    Cite this

    @phdthesis{c536c306f75e45fca4e6025566794948,
    title = "Characterising and improving image quality in optical coherence tomography and elastography by means of optical beam shaping and simulations",
    abstract = "One path to understanding the genesis and progression of disease, and to early disease detection, lies in the advancement of label-free microscopy techniques, such as optical coherence tomography (OCT) and optical coherence elastography (OCE). To this end, this thesis describes the methods used to alter and improve OCT and OCE image quality via beam shaping; to compare it in realistic and controlled turbid tissue scenarios using novel phantoms; and to analyse it with the aid of simulations. With these tools, we characterise the influence of Bessel beams on contrast in OCT, and demonstrate a substantial resolution improvement in ultrahigh-resolution OCE.",
    keywords = "Optical design of instruments, Optical coherence tomography, Laser beam shaping, Tissue characterisation, Numerical approximation and analysis, Light propagation in tissue, Image formation theory, Image enhancement",
    author = "Andrea Curatolo",
    year = "2017",
    language = "English",
    school = "The University of Western Australia",

    }

    TY - THES

    T1 - Characterising and improving image quality in optical coherence tomography and elastography by means of optical beam shaping and simulations

    AU - Curatolo, Andrea

    PY - 2017

    Y1 - 2017

    N2 - One path to understanding the genesis and progression of disease, and to early disease detection, lies in the advancement of label-free microscopy techniques, such as optical coherence tomography (OCT) and optical coherence elastography (OCE). To this end, this thesis describes the methods used to alter and improve OCT and OCE image quality via beam shaping; to compare it in realistic and controlled turbid tissue scenarios using novel phantoms; and to analyse it with the aid of simulations. With these tools, we characterise the influence of Bessel beams on contrast in OCT, and demonstrate a substantial resolution improvement in ultrahigh-resolution OCE.

    AB - One path to understanding the genesis and progression of disease, and to early disease detection, lies in the advancement of label-free microscopy techniques, such as optical coherence tomography (OCT) and optical coherence elastography (OCE). To this end, this thesis describes the methods used to alter and improve OCT and OCE image quality via beam shaping; to compare it in realistic and controlled turbid tissue scenarios using novel phantoms; and to analyse it with the aid of simulations. With these tools, we characterise the influence of Bessel beams on contrast in OCT, and demonstrate a substantial resolution improvement in ultrahigh-resolution OCE.

    KW - Optical design of instruments

    KW - Optical coherence tomography

    KW - Laser beam shaping

    KW - Tissue characterisation

    KW - Numerical approximation and analysis

    KW - Light propagation in tissue

    KW - Image formation theory

    KW - Image enhancement

    M3 - Doctoral Thesis

    ER -