Characterisation of the biology, evolutionary relationships, and host-parasite interactions of Australian Trypanosoma spp.

Crystal Elizabeth Cooper

Research output: ThesisDoctoral Thesis

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Abstract

Trypanosoma spp. are protozoan parasites responsible for a number of important diseases worldwide, although they remain understudied in Australia. High-throughput molecular (NGS) and microscopy (confocal, TEM, SEM, FIB-SEM) techniques combined with In vitro research were used to investigate the diversity and biology of avian and marsupial trypanosomas. A number of novel genotypes were characterised (genetically and morphologically) including a novel species in the Trypanosoma cruzi clade (Trypanosoma noyest). Trypanosoma copemani host-parasite interactions were investigated in vitro and exposure to T. copemani was detrimental to cell health. Future research should focus on understanding the role Australian trypanosomas play in their communities.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date27 Nov 2017
DOIs
Publication statusUnpublished - 2017

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Trypanosoma
host-parasite relationships
Biological Sciences
Trypanosoma cruzi
Metatheria
Protozoa
parasites
genotype
cells
methodology

Cite this

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title = "Characterisation of the biology, evolutionary relationships, and host-parasite interactions of Australian Trypanosoma spp.",
abstract = "Trypanosoma spp. are protozoan parasites responsible for a number of important diseases worldwide, although they remain understudied in Australia. High-throughput molecular (NGS) and microscopy (confocal, TEM, SEM, FIB-SEM) techniques combined with In vitro research were used to investigate the diversity and biology of avian and marsupial trypanosomas. A number of novel genotypes were characterised (genetically and morphologically) including a novel species in the Trypanosoma cruzi clade (Trypanosoma noyest). Trypanosoma copemani host-parasite interactions were investigated in vitro and exposure to T. copemani was detrimental to cell health. Future research should focus on understanding the role Australian trypanosomas play in their communities.",
keywords = "Trypanosomes, Diversity, Parasites, 18S rDNA, Electron microscopy, Marsupials",
author = "Cooper, {Crystal Elizabeth}",
year = "2017",
doi = "10.4225/23/5a38643a3886f",
language = "English",
school = "The University of Western Australia",

}

TY - THES

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AU - Cooper, Crystal Elizabeth

PY - 2017

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N2 - Trypanosoma spp. are protozoan parasites responsible for a number of important diseases worldwide, although they remain understudied in Australia. High-throughput molecular (NGS) and microscopy (confocal, TEM, SEM, FIB-SEM) techniques combined with In vitro research were used to investigate the diversity and biology of avian and marsupial trypanosomas. A number of novel genotypes were characterised (genetically and morphologically) including a novel species in the Trypanosoma cruzi clade (Trypanosoma noyest). Trypanosoma copemani host-parasite interactions were investigated in vitro and exposure to T. copemani was detrimental to cell health. Future research should focus on understanding the role Australian trypanosomas play in their communities.

AB - Trypanosoma spp. are protozoan parasites responsible for a number of important diseases worldwide, although they remain understudied in Australia. High-throughput molecular (NGS) and microscopy (confocal, TEM, SEM, FIB-SEM) techniques combined with In vitro research were used to investigate the diversity and biology of avian and marsupial trypanosomas. A number of novel genotypes were characterised (genetically and morphologically) including a novel species in the Trypanosoma cruzi clade (Trypanosoma noyest). Trypanosoma copemani host-parasite interactions were investigated in vitro and exposure to T. copemani was detrimental to cell health. Future research should focus on understanding the role Australian trypanosomas play in their communities.

KW - Trypanosomes

KW - Diversity

KW - Parasites

KW - 18S rDNA

KW - Electron microscopy

KW - Marsupials

U2 - 10.4225/23/5a38643a3886f

DO - 10.4225/23/5a38643a3886f

M3 - Doctoral Thesis

ER -