Abstract
The airway epithelium is a central component of the lung’s defence system. This PhD thesis has characterised secretory responses of the airway epithelium elicited by acrolein, a key compound contained in smoke, involving the secretion of two major compounds-mucins and PGE2. A novel dynamic ex vivo perfusion model was developed to further characterise acrolein-induced mucin secretion. Additionally, a novel secretory response elicited by acrolein involving epithelial secretion of PGE2 was also discovered and found to be modulated by influenza A infection. Together, these findings provide important insights into secretory responses that serve an important protective function against acrolein.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Award date | 18 Nov 2016 |
Publication status | Unpublished - 2016 |