Characterisation of neonatal cardiac dynamics using ordinal partition network

Laurita dos Santos, Débora C. Corrêa, David M. Walker, Moacir F. de Godoy, Elbert E.N. Macau, Michael Small

Research output: Contribution to journalArticlepeer-review

Abstract

The maturation of the autonomic nervous system (ANS) starts in the gestation period and it is completed after birth in a variable time, reaching its peak in adulthood. However, the development of ANS maturation is not entirely understood in newborns. Clinically, the ANS condition is evaluated with monitoring of gestational age, Apgar score, heart rate, and by quantification of heart rate variability using linear methods. Few researchers have addressed this problem from the perspective nonlinear data analysis. This paper proposes a new data-driven methodology using nonlinear time series analysis, based on complex networks, to classify ANS conditions in newborns. We map 74 time series given by RR intervals from premature and full-term newborns to ordinal partition networks and use complexity quantifiers to discriminate the dynamical process present in both conditions. We obtain three complexity quantifiers (permutation, conditional, and global node entropies) using network mappings from forward and reverse directions, and considering different time lags and embedding dimensions. The results indicate that time asymmetry is present in the data of both groups and the complexity quantifiers can differentiate the groups analysed. We show that the conditional and global node entropies are sensitive for detecting subtle differences between the neonates, particularly for small embedding dimensions (m < 7). This study reinforces the assessment of nonlinear techniques for RR interval time series analysis. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)829-842
Number of pages14
JournalMedical and Biological Engineering and Computing
Volume60
Issue number3
DOIs
Publication statusPublished - Mar 2022

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