Characterisation of low intensity repetitive transcranial magnetic stimulation on cortical astrocytes in mouse and experimental models

Research output: ThesisDoctoral Thesis

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Abstract

The neuromodulatory technique repetitive transcranial magnetic stimulation (rTMS) applies magnetic pulses to the cranium to induce electric fields in the brain, but has unknown effects on glial cells such as astrocytes. This thesis examined low intensity rTMS effects on astrocytes. Two weeks of daily rTMS reduced the number of reactive astrocytes in female mice and increased the number in male mice following a cortical stab injury. rTMS increased cultured astrocyte calcium levels and downregulated gene expression and protein levels of calcium signalling and inflammatory genes. These findings demonstrate that rTMS can change aspects of astrocyte biology.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Rodger, Jennifer, Supervisor
  • Tang, Alex, Supervisor
  • Harvey, Alan, Supervisor
  • Bates, Kristyn, Supervisor
Thesis sponsors
Award date9 Oct 2020
DOIs
Publication statusUnpublished - 2020

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