Repetitive transcranial magnetic stimulation (rTMS) is commonly used to induce neuroplasticity in humans. However, the physiological mechanisms underlying rTMS-induced neuroplasticity remain unclear. This thesis investigates the mechanisms of low-intensity rTMS (LI-rTMS) induced plasticity in the intact and injured nervous systems using rodent and experimental models. In addition, we describe the development and validation of rodent-specific rTMS coils. Our results show that Ll-rTMS induces functional and behavioural plasticity in the intact nervous system but fails to induce neuroplasticity following neurotrauma .The outcomes of this thesis provide critical Insights into the mechanisms and use of rTMS that will inform clinical practice.
|Qualification||Doctor of Philosophy|
|Award date||5 Jan 2017|
|Publication status||Unpublished - 2016|