Characterisation of leukocytes and plasma proteins for biomarker discovery in very preterm infants with late-onset sepsis

Research output: ThesisDoctoral Thesis

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Abstract

Sepsis is a frequent complication among very preterm infants and contributes to mortality and morbidity. Neonatal sepsisis diagnosed by blood culture, a test with variable sensitivity and delayed reporting times. This research explored sepsis-associated changes in leukocyte counts and the plasma proteome to identify clinically useful biomarkers for improving the accuracy and speed of diagnosing late-onset sepsis in preterm infants. We found that sepsis affected several biological systems that were represented by key biomarkers. When combined, these biomarkers accurately identified sepsis, thus improving the speed of diagnosis. Faster diagnosis may support clinical management and facilitate antibiotic stewardship in infants.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Simmer, Karen, Supervisor
  • Strunk, Tobias, Supervisor
  • Currie, Andrew, Supervisor
Thesis sponsors
Award date18 Jul 2022
DOIs
Publication statusUnpublished - 2022

Embargo information

  • Embargoed from 16/08/2022 to 30/06/2023. Made publicly available on 30/06/2023.

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