Characterisation of intra- and extracellular mitochondrial vesicles released by osteocytes

Yao Zong

Research output: ThesisMaster's Thesis

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Abstract

Osteocytes are cells embedded in mineralized bone matrix responsible for mechanotransduction,
which can release extracellular vesicles to regulate bone homeostasis. Mitochondria are the
powerhouse of cells. In recent years, it was demonstrated that osteocytes could release mitochondria
to regulate osteoprogenesis. This project is to investigate whether mitochondria in osteocytes are
released via extracellular vesicles under physiological and stressed conditions, focusing on the
characterization of intracellular mitochondria and mitochondria-related extracellular vesicles. Initial
results indicated that mitochondria-related extracellular vesicles resembled microvesicles in
morphology, but showed no significant difference in expression of mitochondrial outer membrane
proteins after uncoupling treatment.
Original languageEnglish
QualificationMasters
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Zheng, Minghao, Supervisor
  • Wood, David, Supervisor
  • Hao, Hong, Supervisor, External person
Award date24 Oct 2023
DOIs
Publication statusUnpublished - 2023

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